1. Giá trị của định lượng tín hiệu MRI 3.0T trong chẩn đoán ung thư tuyến tiền liệt

Abstract

This cross-sectional descriptive study based on quantitative signal intensity on 3-tesla magnetic resonance imaging (3.0T MRI) was conducted to differentiate prostate cancer (PCa) and non prostate cancer (NPCa) lesions. The study involved 84 patients (PTs) with PSA > 4 ng/ml who underwent 3.0T MRI and transrectal ultrasound-guided prostate biopsy with histopathological results from January to October 2023 at Viet Duc Hospital. The histopathological result was defined as PCa when Gleason score was ≥ 6. The location of PCa was determined based on anatomical zones corresponding to 2 regions on 3.0T MRI (peripheral or central zone). The results showed the mean age was 70.1 ± 7.65 years (ranging from 41 to 82 years), PCa group was 72.6 ± 6.6 years, and NPCa group was 67.7 ± 8.2 years (p < 0.01). Considering lesions in both peripheral and central zones, the signal intensity indices of PCa were consistently lower than the benign group on T2-weighted images (T2W mean), apparent diffusion coefficient (ADC mean and ADC min), while indices on diffusion-weighted imaging (DWI mean and DWI max) were higher (p < 0.01). Moreover, the ROC curve demonstrated that ADC mean was the most accurate in diagnosing PCa with an area under the curve (AUC) of 0.948, sensitivity (Sn) of 92.3%, and specificity (Sp) of 86.7% in the peripheral zone and AUC of 0.991 in the central zone with Sn 97.4% and Sn 86.7%. Additionally, ADC min, T2 mean, DWI mean, DWI max also had high diagnostic value in detecting PCa.