31. Propylene glycol effects on fertility and lifespan in an experimental drosophila melanogaster model
Main Article Content
Abstract
Propylene glycol (PG) is an additive widely used as a solvent, moisturizing, and antifreeze in foods, pharma and cosmetics. In 1982, PG was classified by the FDA (Food and Drug Administration) as GRAS (Generally Recognized As Safe), but there are increasing reports about the toxicity of PG. Therefore, in this study we used the experimental drosophila melanogaster model to evaluate the impact of PG on longevity and fertility. The results showed that flies exposed to 1% PG concentration exhibited a shorter lifetime of 89.7% in females and 86.7% in males in comparison to the control group. In addition, 0.5% PG concentration lowered fertility by 39.74% compared to the controls. Furthermore, 0.1% PG concentration significantly reduced ERR (Estrogen-related receptor) gene expression from day 10 to day 30. Meanwhile, PG concentration at 0.02% and 0.2% increased ERR expression at day 10 and then decreased significantly at age of 20 days. At day 30, ERR expression increased at 0.02% PG but decreased at 0.2% PG. EcR (ecdysone receptor) gene expression in the PG exposed group increased 10 folds compared to the control group at day 10 of age. However, the expression of EcR decreased significantly at day 20 and day 30 with 0.1% and 0.2% PG concentrations. According to the findings of this study, Propylene glycol reduces lifespan and affects reproductive hormone receptors in drosophila melanogaster model. This suggests that more research should be conducted to evaluate the effects of additives on human health.
Article Details
Keywords
Propylene glycol, Drosophiala melanogaster, EcR, ERR gene
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