Đặc điểm lâm sàng, cận lâm sàng và tình trạng kháng kháng sinh của trẻ em bị loét dạ dày tá tràng có nhiễm helicobacterpylori

Abstract

Treatment of gastroduodenal ulcers with H. pylori infection in children is increasingly difficult due to increasing antibiotic resistance. The objective of the study was to describe the clinical, laboratory characteristics and antibiotic resistant of H.pylori - induced gastroduodenal ulcers in children. A prospective study described a case series including 151 children diagnosed with gastroduodenal ulcers with H.pylori infection who were examined and treated at the Vietnam National Children's Hospital from June 2020 to May 2021. The results showed that the mean age of the disease was 9.6 ± 2.5, the ratio of male and female was 4.6:1. Common clinical symptoms were abdominal pain (84,1%), anemia (69.5%) and gastrointestinal bleeding (56,3%). Endoscopic results showed that duodenum ulcer accounted for 93.4%. The rate of H.pylori infection was 74.2%. 98.7% of children were resistant to at least 1 antibiotic with the rate of resistance to amoxicillin, clarithromycin, metronidazole, levofloxacin and tetracycline respectively 88.7%; 96.7%; 30.5%; 9.9% and 0%. Multiantibiotic resistance accounted for 90.7%, of which concurrent resistance to amoxicillin and clarithromycin accounted for 55.0%. Conclusion: Common clinical symptoms of children with gastroduodenal ulcers with H.pylori infection were abdominal pain, anemia, and gastrointestinal bleeding with most of case was duodenal ulcer. The high rate of antibiotic resistance affects the treatment results of gastroduodenal ulcers with H.pylori infection in children.