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Published: 2024-09-11
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DOI: https://doi.org/10.52852/tcncyh.v180i7.2486
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Vol. 180 No. 7 (2024)
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Các bài báo
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Dân, B. V. ., Triều, T. M. L. ., Minh, N. A. ., Lượng, T. V. ., Phương, N. H. ., & Tùng, L. Đình . (2024). 4. Clinical and subclinical characteristics of interstitial lung disease in connective tissue disease. Journal of Medical Research, 180(7), 27-35. https://doi.org/10.52852/tcncyh.v180i7.2486

4. Clinical and subclinical characteristics of interstitial lung disease in connective tissue disease

Bui Van Dan, Tran Minh Long Trieu, Nguyen Anh Minh, Tran Van Luong, Nguyen Hoang Phuong, Le Dinh Tung

Main Article Content

Abstract

Our study aimed to evaluate the frequency and phenotype of interstitial lung disease (ILD) in patients diagnosed with connective tissue disease (CTD). Cross-sectional descriptive study on 49 patients with a confirmed diagnosis of CTD including systemic sclerosis (SSc), systemic lupus erythematosus (SLE), polymyositis/dermatomyositis (PM/DM) and mixed connective tissue disease (MCTD), treated at the Center for Allergy - Clinical Immunology, Bach Mai Hospital from August 2023 to February 2024. The average age of the study subjects was 57.8 ± 12.1 (years), mainly women (∼80%), ILD was definitely diagnosis after CTD at around 18.1 months. SSc is most common in 21/49 cases (42.9%), SLE in 16/49 patients (32.7%), and PM/DM is 9/49 cases (18.4%) and the lowest MCTD group with 3/49 patients (6.1%). About 67.3% of cases present with cough; 87.5% of patients had difficulty breathing on exertion, including 29/49 cases of mMRC = 2; and over 75.5% of cases found ILD signs when auscultating the lungs. Abnormalities on regular chest X-ray can only be detected in 50 - 60% of cases. On HRCT, ground glass opacities, honeycombing, and traction bronchiectasis are the most common types of interstitial lesions. NSIP and UIP are two common patterns in the ILD-CTD group. We found that ILD can be seen in most CTD diseases with different morphology patterns. Therefore, a thorough clinical examination is needed and an early HRCT scan may be taken to avoid missed or delayed ILD diagnosis in the CTD group.

Article Details

Keywords

Connective tissue disease (CTD), Interstitial lung disease (ILD), Non-specific interstitial pneumonia (NSIP), Usual interstitial pneumonia (UIP)

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