8. Đặc điểm nhiễm khuẩn ở bệnh nhân lupus ban đỏ hệ thống

Abstract

Introduction: Infections remain one of the leading causes of the death in systemic lupus erythematosus (SLE). The aims: To evaluate the infection status in patiens with SLE. Method: The prospective, cross sectional study was conducted in 1282 patients with SLE at the Center of Allergy and Clinical Immunology, Bach Mai Hospital for 1 year (from June 1, 2018 to May 31, 2019). Results: Among the patients studied, 220 patients (17.16%) sufferd from infection. Localized infections were the majority at 84.55% (the respiratory was the most orrgan effected by infection, with 37.30%). There was septic in 11.36%, septic shock in 4.09% of cases. CRPhs level increased in only 10% of patients, while procalcitonin level increased in 52.7% of cases. The majority of bacteria found in infections were Staphylococcus aureus in 39.10%, Bacillius species in 17.40%, and tuberculosis in only 4.30%. The majority of patients were treated with corticosteroids in 86.36%, HCQ in 69.5%. The average corticosteroid dose over 7.5 mg/day before 1 month of admission to the hospital was in 66.40% of cases. Conclusions: The respiratory tract infection was the most of organ infetion in SLE, staphylococcus aureus was common etiology. Drugs and dose of corticosteroid associated of infectious processes.