Clinical characteristics and incidence of laryngopharyngeal reflux in patients with chronic rhinosinusitis
Main Article Content
Abstract
This prospective, cross sectional descriptive study was conducted to investigate the rate of laryngopharyngeal reflux in patients with chronic rhinosinusitis and compare the clinical characteristics between 2 groups with LPR and without LPR. 391 patients with chronic rhinosinusitis examined at Hanoi Medical University Hospital, from September 2023 - April 2024 were included in the study. The proportion of patients with laryngopharyngeal reflux (RSI > 13 and RFS > 7) was 254/391 patients, accounting for 65%. The average age of the VMXM group with LPR was 47.37, higher than the group without LPR which was 40.89. There was a gradual increase in the rate of laryngopharyngeal reflux across age groups, the highest was with patients > 60 years old representing 75.4%. The rate of laryngopharyngeal reflux in women was 159/224 (71.0%), higher than men of 95/167 patients (56.9%). VMXM patients with nasal polyps accounted for 16.1% (63/391 patients). The LPR rate in the nasal polyp group was 36/63 (57.1%), without nasal polyps was 218/328 (66.5%), the difference was not statistically significant.
Article Details
Keywords
Chronic rhinosinusitis, laryngopharyngeal reflux
References
2. Piccirillo JF, Thawle SE,Haiduk A, Kramper M, et al. “Indications for sinus surgery: How appropriate are the guidelines?”. Laryngoscope. 1998; 108, p.332-337.
3. Koufman JA. The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury. Laryngoscope. 1991; 101(4 Pt 2 Suppl 53), 1-78.
4. DiBaise JK, Olusola BF, Huerter JV, Quigley EM. Role of GERD in chronic resistant sinusitis: a prospective, open label, pilot trial. Am J Gastroenterol. 2002; 97(4): 843-850.
5. Lechien JR, Saussez S, Hopkins C. Association between laryngopharyngeal reflux, gastroesophageal reflux and recalcitrant chronic rhinosinusitis: A systematic review. Clin Otolaryngol J ENT-UK J Neth Soc Oto-Rhino-Laryngol Cervico-Facial Surg. March 2023: doi:10.1111/coa.14047.
6. Chambers DW, Davis WE, Cook PR, Nishioka GJ, Rudman DT. Long-term outcome analysis of functional endoscopic sinus surgery: correlation of symptoms with endoscopic examination findings and potential prognostic variables. Laryngoscope. 1997; 107: 504-510.
7. Belafsky PC, Postma GN, and Koufman JA. Validity and reliability of the reflux symptom index (RSI). J Voice. 2002; 16(2): 274-277.
8. Belafsky PC, Postma GN, and Koufman JA. The validity and reliability of the reflux finding score (RFS). Laryngoscope. 2001; 111 (8): 1313-1317.
9. Nam-Kyung Yeo, Seung Jin Park, Tae Hoon An. Laryngopharyngeal reflux in chronic rhinosinusitis patients and the role of endoscopic sinus surgery. Auris Nasus Larynx. Volume 49, Issue 4, August 2022, Pages 663-669. doi: 10.1016/j.anl.2021.11.011. Epub 2021 Dec 10.
10. Ayşegül Verim, Lütfü Şeneldir, Barış Naiboğlu. Effect of laryngopharyngeal reflux on the improvement of chronic rhinosinusitis without polyposis after primary endoscopic sinus surgery. Kulak Burun Bogaz Ihtis. Derg 2016; 26(2): 65-72. doi: 10.5606/kbbihtisas.2016.78972.
11. Jér̂ome René Lechien, Sven Saussez, Claire Hopkins. Association between laryngopharyngeal reflux, gastroesophageal reflux and recalcitrant chronic rhinosinusitis: A systematic review. Clinical Oto- laryngology, 2023, 48 (4), pp.501-514. 10.1111/coa.14047. hal-04191700.
12. Mariel R. Benjamin, MD1, Whitney W. Stevens, MD, PhD1, Newton Li, MD1, Sumit Bose, MD1, Leslie C. Grammer. Clinical Characteristics of Patients with Chronic Rhinosinusitis without Nasal Polyps in an Academic Setting. J Allergy Clin Immunol Pract. 2019 March; 7(3): 1010–1016.
13. Nguyễn Thị Huyền, Quản Thành Nam, Lê Thị Tuyết Ngân, Đỗ Lan Hương, Nghiêm Đức Thuận. Mô tả triệu chứng lâm sàng, hình ảnh cắt lớp vi tính và mô bệnh học của viêm mũi xoang mạn tính. Tạp Chí Y Dược Học Quân Sự. 2022; Số 9: 95-107.