36. Results of radical gastrectomy to treat gastric cancer in elderly patients: A retrospective study of 90 clinical cases

Duong Trong Hien, Tran Kien, Trinh Hong Son, Tran Que Son

Main Article Content

Abstract

Gastric adenocarcinoma is a common disease. In 80% of cases, gastric cancers are detected after the age of 65. We conducted a retrospective study including patients over 60 years old treated for gastric cancer at Vietduc University Hospital from January 2019 to December 2022. The aim of this study was to evaluate the short-term safety and long-term benefits of radical gastrectomy for gastric cancer in elderly patients. Nighty patients were included. The mean age was 68.3 years (60 - 93). The male/female ratio was 2.7. The tumor was revealed by epigastralgia, deterioration of performance status, vomiting, and digestive hemorrhages at 85.5%, 40%, 20%, and 11%, respectively. Endoscopy showed that tumors occurred in the lower third, middle third, and upper third at 68.9%, 26.7%, and 4.4%, respectively. According to the TNM, stages I, II, and III were 42.1%, 17.8%, and 40.1%, respectively. Co-morbidities were cardiovascular disease (40% hypertension, 37.8% heart valves), diabetes mellitus (37.8%), and respiratory disease (41.1%). Distal and total gastrectomy were 93.4% and 6.6%. D2 and D2+ lymph nodes radical were 73.3% and 26.7%. Morbidity and mortality were 11.1% and 0%. The mean of hospital stay was 9.6 days (6 - 20), and overall survival was 30.7 months (12 - 43). The overall survival after 1-, 2-, and 3-years was 86.7%, 71.1%, and 63.3%, respectively. In conclusion, radical gastrectomy is feasible and effective for elderly patients. However, radical surgery selection would depend on the patients‘ general condition and co-morbidities.

Article Details

References

1. Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74(3):229-263.
2. Ferlay J, Ervik M, Lam F, Colombet M, Mery L, Piñeros M ea. Global cancer observatory: cancer today. International Agency for Research on Cancer. 2020; 2022(25): https://gco.iarc.who.int/media/globocan/factsheets/populations/704-viet-nam-fact-sheet.pdf.
3. Iwu CD, Iwu-Jaja CJ. Gastric Cancer Epidemiology: Current Trend and Future Direction. 2023; 3(3): 256-268.
4. Díaz Del Arco C, Ortega Medina L, Estrada Muñoz L, Molina Roldán E, García Gómez de Las Heras S, Fernández Aceñero MJ. Impact of Age at Diagnosis on Clinicopathological Features, Prognosis, and Management of Gastric Cancer: A Retrospective Single-Center Experience from Spain. Cancers. 2023; 15(17).
5. Yazici H, Esmer AC, Eren Kayaci A, Yegen SC. Gastrıc cancer surgery in elderly patients: promising results from a mid-western population. BMC Geriatrics. 2023; 23(1): 529.
6. Suematsu H, Kunisaki C, Miyamato H, et al. Laparoscopic Total Gastrectomy for Gastric Cancer in Elderly Patients. In Vivo. 2020; 34(5): 2933-2939.
7. Wakahara T, Ueno N, Maeda T, et al. Impact of Gastric Cancer Surgery in Elderly Patients. Oncology. 2018; 94(2): 79-84.
8. Schendel J, Jost E, Mah M, et al. Gastric cancer management in elderly patients: a population-based study of treatment patterns and outcomes in gastric cancer patients >/= 75 years from Alberta, Canada. Am J Surg. 2021; 221(4): 839-843.
9. Choi Y, Kim N, Kim KW, et al. Gastric Cancer in Older Patients: A Retrospective Study and Literature Review. Ann Geriatr Med Res. 2022; 26(1): 33-41.
10. Mikami K, Hirano K, Futami K, Maekawa T. Gastrectomy with limited surgery for elderly patients with gastric cancer. Asian J Surg. 2018; 41(1): 65-72.
11. Bộ Y tế. Về việc ban hành tài liệu chuyên môn “Hướng dẫn chẩn đoán và điều trị ung thư dạ dày”. 2020.
12. Vo Duy Long, Dang Quang Thong, Tran Quang Dat, et al. Risk factors of postoperative complications and their effect on survival after laparoscopic gastrectomy for gastric cancer. Ann Gastroenterol Surg. 2024; 8(4): 580-594.
13. Tran Hieu Hoc, Nguyen Duy Hieu, Pham Van Phu, Tran Thu Huong, Tran Que Son. Nutritional status of patients undergoing upper gastrointestinal cancer surgery: A cross-sectional study at a single centre. Tap chí Nghiên cứu Y Học. 2021; 148(12E9): 158 - 164.
14. Sasako M, Sakuramoto S, Katai H, et al. Five-year outcomes of a randomized phase III trial comparing adjuvant chemotherapy with S-1 versus surgery alone in stage II or III gastric cancer. J Clin Oncol. 2011; 29(33): 4387-4393.
15. Thế Dương Phạm, Văn Vụ Kim, Tiến Trung Nguyễn, Trung Thông Phạm. Đánh giá kết quả sớm phẫu thuật cắt gần toàn bộ dạ dày vét hạch trong điều trị ung thư dạ dày ở người cao tuổi. Tạp chí Y học Việt Nam. 2023; 507 (130 - 133).
16. Zhou CJ, Chen FF, Zhuang CL, et al. Feasibility of radical gastrectomy for elderly patients with gastric cancer. Eur J Surg Oncol. 2016; 42(2): 303-311.
17. Wong JU, Tai FC, Huang CC. An examination of surgical and survival outcomes in the elderly (65-79 years of age) and the very elderly (>/=80 years of age) who received surgery for gastric cancer. Curr Med Res Opin. 2020; 36(2): 229-233.
18. Fujiwara Y, Fukuda S, Tsujie M, et al. Effects of age on survival and morbidity in gastric cancer patients undergoing gastrectomy. World J Gastrointest Oncol. 2017; 9(6): 257-262.
19. Lim JH, Lee DH, Shin CM, et al. Clinicopathological features and surgical safety of gastric cancer in elderly patients. J Korean Med Sci. 2014;29(12):1639-1645.
20. Jung HS, Park YK, Ryu SY, Jeong O. Laparoscopic Total Gastrectomy in Elderly Patients (>/=70 Years) with Gastric Carcinoma: A Retrospective Study. J Gastric Cancer. 2015; 15(3): 176-182.
21. Ueno D, Matsumoto H, Kubota H, et al. Prognostic factors for gastrectomy in elderly patients with gastric cancer. World J Surg Oncol. 2017; 15(1): 59.
22. Endo S, Yamatsuji T, Fujiwara Y, et al. Prognostic factors for elderly gastric cancer patients who underwent gastrectomy. World J Surg Oncol. 2022; 20(1): 10.