Nghiên cứu độc tính bán trường diễn của viên nang cứng Tiêu thực Kim Linh trên thực nghiệm

Abstract

Dyslipidemia syndrome is one of the important risk factors for the formation and development of atherosclerosis. Tieu Thuc Kim Linh hard capsule is formulated according to the theoretical basis of traditional medicine in treating dyslipidemia, which includes 7 herbal medications. The study was conducted to evaluate the sub-chronic toxicity of Tieu thuc Kim Linh in Wistar rats. The study showed that rats were divided into 3 groups: control; treated with Tieu thuc Kim Linh at the daily dose of 0.42 g/kg per day and 1.26 g/kg per day, respectively, for 4 consecutive weeks. After administration, rats were sacrificed to collect samples for analyzing parameters in blood at the 2^nd week and 4^th week. Histopathological of the liver and kidney were only observed at the 4^th week. The Tieu thuc Kim Linh at 0.42 g/kg per day and 1.26 g/kg per day had no effect on body weight development and hematopoietic functions (no change in the count of erythrocytes, leukocytes, platelets, and hemoglobin amount, the activity of AST, ALT, bilirubin, albumin, cholesterol, and blood creatinine level). No change in the functions of the liver and kidney and no change in their structures observed in rats during the experiment.