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Published: 2024-11-11
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DOI: https://doi.org/10.52852/tcncyh.v183i10.2770
Issue
Vol. 183 No. 10 (2024)
Section
Các bài báo
How to Cite
Anh, Đặng H., Quyên, Đỗ L., & Lợi, V. Đức. (2024). Anti-inflammatory effect of herbal remedy “bai doc tan gia vi” in experimental animals. Journal of Medical Research, 183(10), 320-330. https://doi.org/10.52852/tcncyh.v183i10.2770

Anti-inflammatory effect of herbal remedy “bai doc tan gia vi” in experimental animals

Dang Hong Anh, Do Linh Quyen, Vu Duc Loi

Main Article Content

Abstract

“Bai Doc Tan Gia Vi” is developed based on the traditional formula Bai Doc Tan, and composes of 4 medicinal herbs including Caulis Tinospora sinensis Merr., Rhizoma Reynoutriae japonicae, Folium Ardisiae, Os Sepiae. A study was conducted on experimental animals to evaluate the acute and chronic anti-inflammatory effects of “Bai Doc Tan Gia Vi”. The acute anti-inflammatory effects were assessed using two models: carrageenin-induced paw edema and peritonitis in Wistar rats, with diclofenac as the oral reference drug at 10 mg/kg/day. The chronic anti-inflammatory effects were evaluated using a model of asbestos-induced granuloma in Swiss mice, with prednisolone as the oral positive control drug at 5 mg/kg/day. The research results showed that “Bai Doc Tan Gia Vi” at both doses of 21 g/kg/day and 42 g/kg/day demonstrated a trend of acute anti-inflammatory effects in the models. “Bai Doc Tan Gia Vi” at 72 g/kg/day exhibited significant chronic anti-inflammatory effects by reducing the weight of the granuloma.

Article Details

Keywords

Anti – inflammatory, Bai Doc Tan gia vi, experimental animal

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