Etiologies of thyrotoxicosis and some clinical, subclinical characteristics of patients with thyrotoxicosis at Hanoi Medical University Hospital
Main Article Content
Abstract
Thyrotoxicosis is a common thyroid disorder with multiple etiologies. With the aim of determining the cause of thyrotoxicosis and describing some clinical and subclinical characteristics of patients with thyrotoxicosis at Hanoi Medical University Hospital, we conducted a cross-sectional study on 370 patients treated at Hanoi Medical University Hospital from August 2023 to December 2023. Graves’ disease was the most common cause of thyrotoxicosis, accounting for 82.4%. Other less common causes were subacute thyroiditis (1.6%), solitary toxic adenoma (1.1%), multinodular toxic goiter (0.8%), gestational thyrotoxicosis (3%), and iodine-induced hyperthyroidism (1.1%), due to excess exogenous thyroid hormone (0.8%). Notably, 31 patients (8.3%) were of unknown causes. The average age of patients was 42.32 ± 14.19 years old. The majority of the patients were female, the female/male ratio was 3.2/1. The largest age group was adults aged from 31 to 40 years old, accounting for 28.9%.
Article Details
Keywords
Thyrotoxicosis, Graves’ disease
References
2. Lee SY, Pearce EN. Hyperthyroidism A Review. JAMA. 2023; 330(15): 1472-1483. doi:10.1001/jama.2023.19052.
3. Ross DS, Burch HB, Cooper DS, Greenlee MC, Laurberg P, Maia AL, Rivkees SA, Samuels M, Sosa JA, Stan MN, Walter MA. 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis. Thyroid. 2016; 26(10):1343-1421. doi: 10.1089/thy.2016.0229.
4. Vũ Bích Nga (2022). Bệnh lý rối loạn chức năng tuyến giáp: Cường giáp và suy giáp, Bệnh lý tuyến giáp trong thực hành lâm sàng, Nhà xuất bản y học, chương III: 140 – 231.
5. Iglesias P, Dévora O, García J, Tajada P, García-Arévalo C, Díez JJ. Severe hyperthyroidism: aetiology, clinical features and treatment outcome. Clin Endocrinol (Oxf). 2009; 72: 551–557. doi: 10.1111/j.1365-2265.2009.03682.x.
6. Abraham-Nordling M, Törring O, Lantz M, Hallengren B, Ohrling H, Lundell G, Calissendorff J, Jörneskog G, Wallin G. Incidence of hyperthyroidism in Stockholm, Sweden, 2003-2005. Eur J Endocrinol. 2008; 158(6): 823-7. doi: 10.1530/EJE-07-0877.
7. Baldé N, Kaké A, Sylla D, Diallo A, Diallo M, Diallo M, Diango A, Kourouma L, Bah E, Diallo M, Dieng K and Barry M. Graves’ Disease in 100 Cases in Conakry: Epidemiological, Clinical, Therapeutic, and Evolutionary Aspects. Open Journal of Endocrine and Metabolic Diseases. 2022; 12: 75-81. doi: 10.4236/ojemd.2022.122005.
8. Carlé A, Pedersen IB, Knudsen N, Perrild H, Ovesen L, Rasmussen LB, Laurberg P. Epidemiology of subtypes of hyperthyroidism in Denmark: a population-based study. Eur J Endocrinol. 2011; 164(5): 801-9. doi: 10.1530/EJE-10-1155.
9. Massimo Tonacchera and Dagmar Führer (2018). Toxic Adenoma and Multinodular Toxic, Thyroid Disease, Springer International Publishing AG, 17: 515 – 534. https://doi.org/10.1007/978-3-319-45013-1_18.
10. Hurley, D.L. and Gharib, H. Evaluation and Management of Multinodular Goiter. Otolaryngologic Clinics of North America. 1996; 29: 527-540.
11. Al-Jabri, Abdallah Talib et al. AACE2021-A-1020: Toxic Multinodular Goiter: Epidemiological, Clinical, Biochemical and Radiological Features. Endocrine Practice. 2021; Volume 27, Issue 12, S33. https://doi.org/10.1016/j.eprac.2021.11.050.
12. Petca A, Dimcea DA, Dumitrașcu MC, Șandru F, Mehedințu C, Petca RC. Management of Hyperthyroidism during Pregnancy: A Systematic Literature Review. J Clin Med. 2023; 12(5): 1811. doi: 10.3390/jcm12051811.