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Published: 2025-01-10
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DOI: https://doi.org/10.52852/tcncyh.v186i1.2943
Issue
Vol. 186 No. 1 (2025)
Section
Các bài báo
How to Cite
Nguyên, N. T. T. ., Trai, N. N. ., My, V. D. ., Phương, H. A. ., & Trở, C. V. . (2025). MicroRNA-21 in atrophic scars from acne: A cross-sectional study on 70 patients. Journal of Medical Research, 186(1), 123-131. https://doi.org/10.52852/tcncyh.v186i1.2943

MicroRNA-21 in atrophic scars from acne: A cross-sectional study on 70 patients

Nguyen Tran Thao Nguyen, Nguyen Ngoc Trai , Vu Diem My , Huynh Anh Phuong, Chau Van Tro

Main Article Content

Abstract

Atrophic scars (AS) -one of the most popular complications of acne vulgaris (AV)-do not affect  human health but greatly impact the patient’s aesthetic and quality of life. However, the pathophysiological mechanisms of these scars are not clearly understood. Recently, with advancements in molecular biology, microRNA-21 has been identified as a potential factor closely associated with the development of atrophic scars. To assess the relative level of microRNA-21 in plasma and compare between patients with and without atrophic scars, we conducted a cross-sectional study involving 70 acne patients at the Ho Chi Minh City Dermatology Hospital from 04/2024 to 09/2024. Among 70 patients, 35 had AS (Group A), while 35 had no AS (Group B).  The mean relative level of microRNA-21 in patients with acne was 2.758 ± 5.01. Furthermore, levels of microRNA-21 in group A (3.773 ± 6.733) were higher than group B (1.742 ± 1.864), (p = 0.01).  No significant difference in  microRNA-21 levels  was observed across varying severities of acne.  However, patients  with mild scars  showed the highest levels (p = 0.045).

Article Details

Keywords

acne vulgaris, atrophic scar, microRNA-21

References

1. Yakupu A, Aimaier R, Yuan B, et al. The burden of skin and subcutaneous diseases: findings from the global burden of disease study 2019. Frontiers in public health. 2023;11:1145513. doi:10.3389/fpubh. 2023.1145513
2. Ghodsi SZ, Orawa H, Zouboulis CC. Prevalence, severity, and severity risk factors of acne in high school pupils: a community-based study. The Journal of investigative dermatology. Sep 2009;129(9):2136-41. doi:10.1038/jid.20 09.47
3. Cotterill JA, Cunliffe WJ. Suicide in dermatological patients. The British journal of dermatology. Aug 1997;137(2):246-50. doi:10.1046/j.1365-2133.1997.18131897.x
4. Dréno B, Tan J, Kang S, et al. How People with Facial Acne Scars are Perceived in Society: an Online Survey. Dermatology and therapy. Jun 2016;6(2):207-18. doi:10.1007/s13555-016-0113-x
5. Tan J, Kang S, Leyden J. Prevalence and Risk Factors of Acne Scarring Among Patients Consulting Dermatologists in the USA. Journal of drugs in dermatology : JDD. Feb 1 2017;16(2):97-102.
6. Jennings T, Duffy R, McLarney M, et al. Acne scarring-pathophysiology, diagnosis, prevention and education: Part I. Journal of the American Academy of Dermatology. Jun 2024;90(6):1123-1134. doi:10.1016/j.jaad. 202 2.04.021
7. Wang JV, Saedi N. The utility of understanding atrophic acne scar formation for prevention and treatment. The British journal of dermatology. Oct 2018;179(4):819. doi:10.1111/bjd.17020
8. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. Jan 23 2004;116(2):281-97. doi:10.1016/s0092-8674(04)00045-5
9. Yu X, Wang M, Li L, et al. MicroRNAs in atopic dermatitis: A systematic review. Journal of cellular and molecular medicine. Jun 2020;24(11):5966-5972. doi:10.1111/jcmm. 15208
10. Timis TL, Orasan RI. Understanding psoriasis: Role of miRNAs. Biomedical reports. Nov 2018;9(5):367-374. doi:10.3892/br.2018.1146
11. Mansuri MS, Singh M, Dwivedi M, et al. MicroRNA profiling reveals differentially expressed microRNA signatures from the skin of patients with nonsegmental vitiligo. The British journal of dermatology. Nov 2014;171(5):1263-7. doi:10.1111/bjd.13109
12. Zhu H, Li Y, Qu S, et al. MicroRNA expression abnormalities in limited cutaneous scleroderma and diffuse cutaneous scleroderma. Journal of clinical immunology. Jun 2012;32(3):514-22. doi:10.1007/s10875-011-9647-y
13. Ghumra W, Lee N, Whitehouse H, et al. MicroRNAs as biomarkers of atrophic scarring in acne: a cross-sectional analysis of 41 patients. Clinical and experimental dermatology. Dec 2021;46(8):1495-1503. doi:10.1111/ced.14792
14. Goodman GJ, Baron JA. Postacne scarring: a qualitative global scarring grading system. Dermatologic surgery: official publication for American Society for Dermatologic Surgery [et al]. Dec 2006;32(12):1458-66. doi:10.1111/j.1524-4725.2006.32354.x
15. Wu H, Wang J, Ma H, et al. MicroRNA-21 inhibits mitochondria-mediated apoptosis in keloid. Oncotarget. Nov 3 2017;8(54):92914-92925. doi:10.18632/oncotarget.21656
16. Zhou R, Zhang Q, Zhang Y, et al. Aberrant miR-21 and miR-200b expression and its pro-fibrotic potential in hypertrophic scars. Experimental cell research. Dec 10 2015;339(2):360-6. doi:10.1016/j.yexcr.2015. 10.018