22. Evaluation of changes in CRP levels in predicting mortality risk in patients with bloodstream infections
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Abstract
Bloodstream infection is a serious condition that can progress to septic shock and death. The aim of this study was to evaluate the changes in CRP levels in predicting mortality in patients with bloodstream infection. We conducted a cross-sectional study, enrolling 192 patients diagnosed with bloodstream infection admitted to Hanoi Medical University Hospital from January 2021 to December 2023. The median age of the patients was 62.5 years (IQR: 54.0 – 75.0), with 57.3% being over 60 years old and 66.1% being male. Most patients (75.0%) had underlying conditions. The most common conditions were diabetes (37.5%) and cardiovascular diseases (28.1%). 96.4% of patients had an initial CRP (CRP1) level ≥ 10 mg/L within the first 24 hours of admission , with no statistically significant difference between survivors and non-survivors (p > 0.05). However, CRP levels from day 5 to day 7 (CRP2) were significantly higher in the deceased group (median 112.8 mg/L, IQR: 47.5 – 161.6) compared to the survivor group (median 41.0 mg/L, IQR: 16.9 – 82.4) (p < 0.01). A change in CRP levels (∆CRP) ≤ 50 mg/L after 5 days was a predictor of mortality (OR: 4.30, 95% CI: 1.51 – 12.26, p = 0.006). The area under the ROC curve (AUC) for ∆CRP was 0.734 (95% CI: 0.63 – 0.84, p < 0.01), indicating moderate prognostic accuracy.
Article Details
Keywords
CRP, bloodstream infection, change in CRP
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