Đánh giá tình trạng tái phát và các yếu tố liên quan trong điều trị ung thư niêm mạc má tại Bệnh viện K

Abstract

Buccal mucosa represents a prevalent anatomical site for oral cavity malignancies, wherein recurrence patterns and disease-free survival (DFS) constitute critical prognostic determinants. This investigation sought to elucidate the characteristics of recurrence, disease-free survival metrics, and their associated clinicopathological parameters within this patient cohort. A retrospective analysis was conducted on 56 patients who underwent treatment for buccal mucosa carcinoma at K Hospital between January 2017 and January 2023. The analytical framework encompassed recurrence patterns, DFS rates, and their correlations with pathological characteristics. The study showed that the median follow-up duration extended to 41 months (range: 5 - 65 months). The observed recurrence rate was 39.3%, with local recurrence predominating (90.9%) and nodal recurrence comprising 9.1%. The 5-year DFS rate attained 36.2%. Lymph node metastasis demonstrated significant influence on both recurrence rates (p < 0.05) and DFS outcomes, yielding 5-year DFS rates of 58.5% and 13.3% for node-negative and node-positive cases, respectively (p < 0.01). Disease stage exhibited a significant inverse correlation with DFS rates (p < 0.01), manifesting 3-year DFS rates of 100%, 63.4%, 45.7%, and 20.8% for stages I, II, III, and IV, respectively. In conlusion, the majority of recurrences manifested within the initial two-year period, predominantly as local recurrence. Furthermore, this investigation substantiates the significant correlation between lymph node metastasis and disease stage with DFS outcomes in buccal mucosa carcinoma patients.