42. Report on 15 cases of necrotizing pneumonia caused by Staphylococcus Aureus in neonates
Main Article Content
Abstract
This case series study describes the clinical characteristics, laboratory findings, and treatment outcomes of necrotizing pneumonia caused by Staphylococcus aureus in neonates at the Neonatal Center, National Children's Hospital, from January 2022 to June 2023. Among the 15 children, the admission rates due to fever (100%) and respiratory failure (100%). Laboratory results showed white blood cells (≥ 20 G/L) in 53.3% and C-reactive protein (CRP) levels ≥ 50 mg/L in 93.3%. Chest X-rays revealed nodular opacities in 100% of cases and lobar consolidation in 86.7%. From chest CT scan, unilateral lung necrosis was seen (73.3%) mostly concentrated in one lobe (60%) and mainly in the right lower lobe (33.3%); 86.7% had pleural effusion and 80% with pneumothorax. S. aureus was isolated from pleural fluid (60%), endotracheal tube (53.3%), 60% positive blood cultures. Methicillin-resistant S. aureus (MRSA) accounted for 100% of isolates. All patients were treated with a combination of antibiotics with Vancomycin. Average treatment time was 22.8 ± 9.7 days, rate of pleural drainage (53.3%), lung lobectomy (13.3%). The mortality rate was 20% attributed to multiple complications including respiratory failure (100%), septic shock (53.3%) and, tension pneumothorax (40%). Treatment failure with vancomycin occurred in 53.3%. Diverse disease manifestations, complications and high mortality require timely diagnosis and treatment.
Article Details
Keywords
Necrotizing pneumonia, Staphylococcus aureus, neonates
References
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