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Published: 2025-04-28
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DOI: https://doi.org/10.52852/tcncyh.v189i4.3350
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Vol. 189 No. 4 (2025)
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Các bài báo
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Tuệ, N. T., & Linh, N. T. H. (2025). 11. The role of GLRA2 in the association with autism spectrum disorder in a drosophila melanogaster model. Journal of Medical Research, 189(4), 100-109. https://doi.org/10.52852/tcncyh.v189i4.3350

11. The role of GLRA2 in the association with autism spectrum disorder in a drosophila melanogaster model

Nguyen Trong Tue, Ngo Thi Huyen Linh

Main Article Content

Abstract

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by impairments in communication, social interaction, language development, and repetitive behaviors. Recent studies have suggested a link between the GLRA2 gene and ASD. In this study, we utilized the GAL4/UAS system to reduce GLRA2 gene expression in the Drosophila brain in order to assess the role of this protein in social interaction, locomotion, and sleep-wake rhythms. The results showed that GLRA2 knockdown did not significantly affect locomotor ability but markedly impaired social interaction and disrupted sleep-wake rhythms. These findings further support the role of GLRA2 in ASD and provide a potential model for studying its pathogenesis and screening therapeutic interventions.

Article Details

Keywords

Autism Spectrum Disorder, Drosophila, GLRA2, Glycine Alpha 2

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