Treatment outcome of nephrobalstoma treated with siop protocol in National Children’s Hospital
Main Article Content
Abstract
Wilms tumor is one of the most common solid tumors in children. This study aimed to evaluate treatment outcomes following the SIOP protocol at the Vietnam National Children’s Hospital in 72 patients histologically diagnosed from January 2018 to August 2024. The mean age at diagnosis was 23 months (ranging from 1 day to 72 months), with a female predominance. Left-sided tumors accounted for 45.2%, right-sided for 42.4%, and bilateral tumors for 10.9%. The 5-year overall survival (OS) and event-free survival (EFS) rates were 89.6% and 84.9%, respectively. The low- and intermediate-risk groups had a higher EFS rate compared to the high-risk group (91% vs. 80%). Patients with post-treatment tumor volume < 500cm³ had higher OS and EFS rates than those with ≥ 500cm³. The recurrence and mortality rates were 7% and 9.7%, respectively. Treatment outcomes following the SIOP protocol at the Vietnam National Children’s Hospital were favorable, highlighting the prognostic significance of risk stratification and post-treatment tumor volume.
Article Details
Keywords
Wilms tumor, treatment outcomes, SIOP protocol
References
2. Bhatnagar S. Management of Wilms’ tumor: NWTS vs SIOP. Journal of Indian Association of Pediatric Surgeons. 2009; 14(1): 6. doi:10.4103/0971-9261.54811.
3. Powis M, Messahel B, Hobson R, Gornall P, Walker J, Pritchard-Jones K. Surgical complications after immediate nephrectomy versus preoperative chemotherapy in non-metastatic Wilms’ tumour: findings from the 1991-2001 United Kingdom Children’s Cancer Study Group UKW3 Trial. J Pediatr Surg. 2013; 48(11): 2181-2186. doi:10.1016/j.jpedsurg.2013.07.001.
4. Vũ Trường Nhân. Đánh giá kết quả điều trị bướu Wilms ở trẻ em giai đoạn II–IV bằng chiến lược hóa – phẫu trị [luận án Tiến sĩ y khoa]. TP. Hồ Chí Minh: Đại học Y Dược TP. Hồ Chí Minh; 2020.
5. Graf N, van Tinteren H, Bergeron C, et al. Characteristics and outcome of stage II and III non-anaplastic Wilms’ tumour treated according to the SIOP trial and study 93-01. European Journal of Cancer. 2012; 48(17): 3240-3248. doi:10.1016/j.ejca.2012.06.007.
6. Agrawal V, Mishra A, Yadav SK, et al. A 10-Year Study of the Outcome of Wilms’ Tumor in Central India and Identifying Practice Gaps. J Indian Assoc Pediatr Surg. 2022; 27(1): 42-52. doi:10.4103/jiaps.JIAPS_314_20.
7. Reinhard H, Semler O, Bürger D, et al. Results of the SIOP 93-01/GPOH trial and study for the treatment of patients with unilateral nonmetastatic Wilms Tumor. Klin Padiatr. 2004; 216(3): 132-140. doi:10.1055/s-2004-822625.
8. Anyanwu LJC, Atanda AT, Atanda JO. Wilms’ tumour in African children: Can an institutional approach improve outcome? Afr J Paediatr Surg. 2015; 12(1): 7-11. doi:10.4103/0189-6725.150926.
9. Rančelytė M, Nemanienė R, Ragelienė L, Rascon J. Wilms tumour in children: 18 years of experience at Vilnius University Hospital Santaros Klinikos, Lithuania. Acta Med Litu. 2019; 26(2): 125-133. doi:10.6001/actamedica.v26i2.4033.
10. Holmes DM, Matatiyo A, Mpasa A, et al. Outcomes of Wilms tumor therapy in Lilongwe, Malawi, 2016-2021: Successes and ongoing research priorities. Pediatr Blood Cancer. 2023; 70(5): e30242. doi:10.1002/pbc.30242.
11. Reddy K, Zyl A van, Uys R, Kruger M. Outcome of two cohorts with nephroblastoma treated with consecutive International Society of Paediatric Oncology protocols in a South African paediatric oncology unit. South African Journal of Child Health. Published online October 19, 2023: 146-151. doi:10.7196/SAJCH.2023.v17i3.1962.