Article Sidebar

PDF (Tiếng Việt)
Published: 2025-09-30
Abstract Views: 0
Views PDF (Tiếng Việt): 0
DOI: https://doi.org/10.52852/tcncyh.v194i9.3877
Issue
Vol. 194 No. 9 (2025)
Section
Các bài báo
How to Cite
Hồng, H. T. M., & Tâm, D. M. (2025). 64. Assessment of neurocognitive disorder in patients with paranoid schizophrenia at the national institute of mental of health - Bach Mai Hospital. Journal of Medical Research, 194(9), 630-641. https://doi.org/10.52852/tcncyh.v194i9.3877

64. Assessment of neurocognitive disorder in patients with paranoid schizophrenia at the national institute of mental of health - Bach Mai Hospital

Hoang Thi Mai Hong, Duong Minh Tam

Main Article Content

Abstract

To describe the prevalence of neurocognitive disorder and associated factors in patients with paranoid schizophrenia, a cross-sectional study was conducted on 91 patients at the National Institute of Mental Health – Bach Mai hospital, from August 2024 to March 2025. Data were collected through interviews with patients using a questionnaire designed for the study. The prevalence of neurocognitive disorder in this study was 79.1% (95% CI: 69.3% - 86.9%). Factors associated with neurocognitive disorder included duration of illness (OR = 3,83; 95% CI: 1,30 – 11.29, p < 0.05), number of relapses (OR = 5.60; 95% CI: 1.80 – 17.38; p < 0,05), disorganized speech (OR = 5.73; 95% CI: 1.23 – 26.71; p < 0.05) and negative symptoms (OR = 4.52; 95% CI: 0.97 - 21.16; p < 0.05). The study revealed that hospitalized paranoid schizophrenia patients have a high prevalence of neurocognitive disorder, which highlights the critical need for routine diagnosis and treatment neurocognitive disorder in clinical practice.

Article Details

Keywords

Paranoid schizophrenia, neurocognitive disorder

References

1. Charlson FJ, Ferrari AJ, Santomauro DF, et al. Global Epidemiology and Burden of Schizophrenia: Findings From the Global Burden of Disease Study 2016. Schizophr Bull. 2018; 44(6): 1195-1203. doi:10.1093/schbul/sby058.
2. Nuechterlein KH, Ventura J, Subotnik KL, Bartzokis G. The Early Longitudinal Course of Cognitive Deficits in Schizophrenia. J Clin Psychiatry. 2014; 75(0 2): 25-29. doi:10.4088/JCP.13065.su1.06.
3. McCleery A, Nuechterlein KH. Cognitive impairment in psychotic illness: prevalence, profile of impairment, developmental course, and treatment considerations. Dialogues Clin Neurosci. 2019; 21(3): 239-248. doi:10.31887/DCNS.2019.21.3/amccleery.
4. Georgiou R, Lamnisos D, Giannakou K. Anticholinergic Burden and Cognitive Performance in Patients With Schizophrenia: A Systematic Literature Review. Front Psychiatry. 2021; 12: 779607. doi:10.3389/fpsyt.2021.779607.
5. Nuechterlein KH, Barch DM, Gold JM, Goldberg TE, Green MF, Heaton RK. Identification of separable cognitive factors in schizophrenia. Schizophr Res. 2004; 72(1): 29-39. doi:10.1016/j.schres.2004.09.007.
6. Heinrichs RW, Zakzanis KK. Neurocognitive deficit in schizophrenia: A quantitative review of the evidence. Neuropsychology. 1998; 12(3): 426-445. doi:10.1037/0894-4105.12.3.426
7. Regression-based normative scores for the Montreal Cognitive Assessment (MoCA) in an Asian population. Scientific Reports. https://www.nature.com/articles/s41598-025-03167-5.
8. Arunpongpaisal S, Sangsirilak A. Using MoCA-Thai to evaluate cognitive impairment in patients with schizophrenia. J Med Assoc Thail Chotmaihet Thangphaet. 2013; 96(7): 860-865.
9. Peng XJ, Hei GR, Li RR, et al. The Association Between Metabolic Disturbance and Cognitive Impairments in Early-Stage Schizophrenia. Front Hum Neurosci. 2021; 14: 599720. doi:10.3389/fnhum.2020.599720.
10. Đoàn Văn Sỹ, Nguyễn Văn Tuấn, Nguyễn Thành Long. Một số yếu tố liên quan đến suy giảm nhận thức ở bệnh nhân tâm thần phân liệt. Tạp Chí Học Việt Nam. 2021; 506(2). doi:10.51298/vmj.v506i2.1295.
11. Mascio A, Stewart R, Botelle R, et al. Cognitive Impairments in Schizophrenia: A Study in a Large Clinical Sample Using Natural Language Processing. Front Digit Health. 2021; 3. doi:10.3389/fdgth.2021.711941.
12. Kao YC, Liu YP. Effects of age of onset on clinical characteristics in schizophrenia spectrum disorders. BMC Psychiatry. 2010; 10: 63. doi:10.1186/1471-244X-10-63.
13. Vương Thị Thủy, Đoàn Thị Như Yến, Lương Thị Mai Loan. Nghiên cứu đặc điểm lâm sàng và một số yếu tố liên quan đến suy giảm nhận thức ở bệnh nhân tâm thần phân liệt thể paranoid tại bệnh viện Tâm thần Hải Phòng năm 2021. Tạp Chí Học Việt Nam. 2022; 515(Đặc biệt).
14. Rund BR, Melle I, Friis S, et al. The course of neurocognitive functioning in first-episode psychosis and its relation to premorbid adjustment, duration of untreated psychosis, and relapse. Schizophr Res. 2007; 91(1): 132-140. doi:10.1016/j.schres.2006.11.030.
15. Talreja BT, Shah S, Kataria L. Cognitive function in schizophrenia and its association with socio-demographics factors. Ind Psychiatry J. 2013; 22(1): 47-53. doi:10.4103/0972-6748.123619.
16. González-Pablos E, Ayuso-Lanchares A, Botillo-Martín C, Martín-Lorenzo C. Relationship between disorganised speech, cognitive functions, and social functioning in people with schizophrenia. Behav Psychol Conduct. 2023; 31(1): 165-178. doi:10.51668/bp.8323110n.
17. Melillo A, Giordano GM, Caporusso E, et al. Association between cognitive deficits and negative symptoms: a systematic review of the literature. Eur Psychiatry. 2023; 66(Suppl 1): S1046-S1047. doi:10.1192/j.eurpsy.2023.2220.