44. Đặc điểm dịch tễ và kháng thuốc của Acinetobacter baumannii trong viêm phổi thở máy tại Bệnh viện Đại học Y Hà Nội

Abstract

Acinetobacter baumannii is a common pathogen in patients with ventilator-associated pneumonia (VAP) in most intensive care units (ICUs)- but the high antibiotic resistance rate of this organism presents a significant treatment challenge. We conducted a study to determine the prevalence of VAP caused by A.baumannii and to describe the antimicrobial resistance patterns of isolates at Hanoi Medical University Hospital. This cross-sectional descriptive study included 89 patients diagnosed with VAP and positive A.baumannii cultures from sputum samples between May 2024 and May 2025. The male-to-female ratio was 2.7:1, and the mean age was 66.8 ± 2.05 years old. The average duration of mechanical ventilation was 19.64 ± 16.37 days. Among VAP cases, the prevalence of A.baumannii infection was 20.5%. The resistance rate to carbapenems reached 88.2%. Treatment by Colistin remained effective; however, there was a trend of increasing MIC values, with a notable proportion of isolates exhibiting MIC ≥1 µg/mL. As VAP due to A.baumannii remains prevalent and highly drug-resistant, identifying epidemiological factors and resistance status contributes to raising awareness and guiding the development of alternative antibiotic regimens.