52. Độc tính cấp và độc tính bán trường diễn của “xịt xoang Triệu Minh” trên thực nghiệm

Abstract

This study aimed to evaluate the acute and subchronic toxicity in experimental models of “Xit Xoang Trieu Minh”. This traditional medicine product is used for treatment of upper respiratory infections and inflammation. The acute toxicity assessment was conducted on Swiss albino mice by administering increasing oral doses of a 3-fold diluted solution of the original product to determine the minimum lethal dose (causing 100% mortality) and the maximum tolerated dose (causing no mortality). The subchronic toxicity was evaluated following WHO guidelines on Wistar rats, using daily oral doses of 1 mL/kg/day (clinically equivalent dose) and 3 mL/kg/day (three times the clinical dose) over 30 days. Results showed that oral administration of “Xit Xoang Trieu Minh” at 100 mL/kg of diluted solution (equivalent to 33.3 mL/kg of the undiluted product) did not cause mortality or any observable abnormal signs in mice. Body weight, hematological parameters, serum biochemistry, and liver and kidney histopathological morphology remained unchanged at 1 mL/kg/day and 3 mL/kg/day doses. However, , 3 out of 10 rats of the 3 mL/kg/day group died during the study, accompanied by signs of reduced activity and appetite. Since the causal relationship between the deaths and the test substance could not be established, further monitoring and in-depth investigation are warranted.