48. An experimental study on the antipyretic effect of FTK syrup
Main Article Content
Abstract
FTK syrup is a multi-herbal syrup formulated for antipyretic purposes. This study was conducted to evaluate the antipyretic activity of FTK syrup on an experimental fever model induced by carrageenan in rabbits. Healthy New Zealand White rabbits were randomly divided into three groups: a model group (treated with distilled water), a positive control group (treated with paracetamol at 100 mg/kg, divided into two administrations at 1 hour and 7 hours following fever induction), and a test group (treated with FTK syrup at of 7.2 mL/kg, divided into two administrations at 1 hour and 7 hours following fever induction). Rectal temperatures were measured before fever induction and then hourly for 12 hours. The results showed that FTK syrup significantly lowered body temperature compared to the model group at the 4th hour (0.98 ± 0.78°C, p < 0.001) and 5th hour (1.45 ± 0.46°C, p < 0.05), with the antipyretic effect lasting up to the 9th hour. The temperature reduction observed with FTK syrup was comparable to that of paracetamol. These findings suggest that FTK syrup exhibits a significant antipyretic effect in the carrageenan-induced fever model in rabbits.
Article Details
Keywords
FTK syrup, carrageenan, fever, antipyretic effect, New Zealand White rabbits
References
2. Akbari H, Mirfazaelian H, Safaei A, et al. Predicting mortality in geriatric patients with fever in the emergency departments: a prospective validation study. BMC Geriatr. 2024;24(1):758. doi:10.1186/s12877-024-05346‑x
3. Maini A, Singh A, Kaur B, et al. Fever in Older Persons. J Indian Acad Geriatr. 2024;20(2):81‑84. doi:10.4103/jiag.jiag_3_24
4. Caparrotta TM, Antoine DJ, Dear JW. Are some people at increased risk of paracetamol‑induced liver injury? Eur J Clin Pharmacol. 2018;74(2):147-160. doi:10.1007/s00228‑017‑2356‑6
5. Chiew AL, Domingo G, Buckley NA, et al. Hepatotoxicity in a child following an accidental overdose of liquid paracetamol. Clin Toxicol (Phila). 2020;58(11):1063-1066. doi:10.1080/15563650.2020.1722150
6. Costello AH, Hargreaves KM. Suppression of carrageenan‑induced hyperalgesia, hyperthermia and edema by a bradykinin antagonist. Eur J Clin Pharmacol. 1989;171(2‑3):259-263. doi:10.1016/0014‑2999(89)90118‑0
7. Sridhar N, Lakshmi DS, Goverdhan P. Effect of ethanolic extracts of Justicia neesii Ramam against experimental models of pain and pyrexia. Indian J Pharmacol. 2015;47(2):177–180. doi:10.4103/0253‑7613.153425
8. Vogel HG, Vogel WH, Schölkens BA, et al. Drug Discovery and Evaluation: Pharmacological Assays. 2nd ed. Berlin, Heidelberg: Springer‑Verlag; 2002:1113-1115. doi:10.1007/3-540-29837-1
9. Conti B. Prostaglandin E₂ that triggers fever is synthesized through an endocannabinoid‑dependent pathway. Temperature (Austin). 2016;3(1):25-27. doi:10.1080/23328940.2015.1130520
10. Widyarini S, Sugiyono, Akrom AM, et al. Carrageenan-induced acute inflammation on back-skin of mice: Histopathological features, number of inflammatory cells, and expression of COX-2, COX-1, and IL-6. World Vet J. 2023;13(4):520-530. doi:10.54203/scil.2023.wvj55
11. Yang X, Meng QG. Reducing fever chemistry of Scutellaria. Chin Arch Tradit Chin Med. 2009;27(6):1183. doi:10.13193/j.archtcm.2009.06.64.yangx.044
12. Li Q, Ge X. Effect of baicalin on antipyresis and influence on cytokine. Zhongguo Zhong Yao Za Zhi. 2010;35(8):1068-1072. doi:10.4268/cjcmm20100829
13. Woo KJ, Lim JH, Suh SI, et al. Differential inhibitory effects of baicalein and baicalin on LPS-induced cyclooxygenase-2 expression through inhibition of C/EBPβ DNA-binding activity. Immunobiology. 2006;211(5):359-368. doi:10.1016/j.imbio.2006.02.002
14. Xi C, Zhang M, Li B, et al. Metabolomics of the anti-inflammatory effect of Pueraria lobata and Pueraria lobata var. Thomsonii in rats. J Ethnopharmacol. 2023;306:116144. doi:10.1016/j.jep.2023.116144
15. Ahirrao P, Deshmukh KN, Menon T, et al. Enhanced anti-inflammatory effect of puerarin. Biol Pharm Bull. 2024;47(12):2154-2164. doi:10.1248/bpb.b23-00885
16. Sun X, Yang Z, Sun D, et al. Saikosaponin A reduces body temperature in febrile rats. Chin Pharmacol Bull. 2016;24(9):1212-1215. doi:10.13193/j.issn.1673-7717.2016.10.065
17. Wang H, Wang M, Li X. Evaluation of the antipyretic activity of Gypsum Fibrosum and its constituents. Asian J Tradit Med. 2009;4(2):82-84. doi:10.1016/j.ajtm.2009.07.002
18. Liu CH, Lin YW, Tang NY, et al. Effect of oral administration of Pheretima aspergillum (earthworm) in rats with cerebral infarction induced by middle-cerebral artery occlusion. Afr J Tradit Complement Altern Med. 2013;10(1):66-82. doi:10.4314/ajtcam.v10i1.9
19. Wahab S, Annadurai S, Abullais SS, et al. Glycyrrhiza glabra (Licorice): A comprehensive review on its phytochemistry, biological activities, clinical evidence, and toxicology. Plants (Basel). 2021;10(12):2751. doi:10.3390/plants10122751
20. Zhang L, Wei W. Anti-inflammatory effects of paeoniflorin and glucosides of paeony. Pharmacol Ther. 2020;207:107452. doi:10.1016/j.pharmthera.2019.107452