54. Assessment of the in vitro biological activities of curcuma zedoaria rhizome ethanol extract
Main Article Content
Abstract
The study of phytochemicals in medicinal plants is increasingly becoming popular due to their numerous pharmacological effects. This research aims to evaluate the antioxidant and anti-inflammatory properties, as well as the anticancer activities against human breast cancer cells MCF-7, of the Curcuma zedoaria ethanol (EtOH) extract. The antioxidative activity of the EtOH extract was assessed using the DPPH assay, while its anti-inflammatory effects were evaluated through the nitric oxide assay employing the Griess reaction. The antiproliferative effects of the extract were analyzed using the sulforhodamine B (SRB) assay. The findings indicated that the EtOH extract exhibited weak antiproliferative activity, with a concentration-dependent response for the MCF-7 cell line. Additionally, the extract displayed significant antioxidant activity, with an IC50 value recorded at 95.47 ± 2.14 mg/mL. Furthermore, the extract showed anti-inflammatory effects, inhibiting NO production with an IC50 value of 58.14 ± 3.11 µg/mL. This research offers a basis for further studies on Curcuma zedoaria, particularly regarding the potential identification of unique bioactive compounds that exhibit therapeutic effects.
Article Details
Keywords
Curcuma zedoaria, antioxidant, anti-inflammatory, MCF-7, DPPH, nitric oxide
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