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Published: 2025-10-31
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DOI: https://doi.org/10.52852/tcncyh.v195i10.4026
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Vol. 195 No. 10 (2025)
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Dinh, T. T., Việt, N. H., Lan, N. N., & Thuý, N. T. (2025). 4. Single nucleotide polymorphism rs2856718 of HLA-DQ gene in nasopharyngeal carcinoma patients infected with EBV. Journal of Medical Research, 195(10), 30-37. https://doi.org/10.52852/tcncyh.v195i10.4026

4. Single nucleotide polymorphism rs2856718 of HLA-DQ gene in nasopharyngeal carcinoma patients infected with EBV

Tran Thi Dinh, Nguyen Hoang Viet, Nguyen Ngoc Lan, Nguyen Thu Thuy

Main Article Content

Abstract

Nasopharyngeal carcinoma (NPC) is the malignant disease related to Epstein-Barr virus (EBV) infection. The HLA-DQ gene encodes receptor proteins on the surface of antigen presenting cells that play a critical role in recognizing and triggering immune response to EBV. Single nucleotide polymorphisms in HLA-DQ gene may influence NPC. This study investigated the association between the HLA-DQ rs2856718 and NPC risk in 109 patients and 129 healthy controls. The genotype frequencies of AA, AG, GG were 26.6%, 53.2%, 20.2% in the patient group and 19.4%, 48.1%, 32.6% in the control group, respectively. The G allele associated with a reduced risk of NPC (OR = 0.675; 95% CI = 0.469 - 0.969; p = 0.033). The GG genotype also decreased the risk in two genetic models: GG vs. AA (OR = 0.452; 95% CI = 0.215 - 0.949; p = 0.036) and GG vs. (AA + AG) (OR = 0.524; 95% CI = 0.289 - 0.950; p = 0.033). These findings suggest that the G allele and GG genotype of rs2856718 may exert a protective effect and contribute to the decrease of NPC risk in EBV-infected individuals.

Article Details

Keywords

SNP rs2856718, HLA-DQ, nasopharyngeal carcinoma, EBV

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