13. Short-term outcomes of pancreatic head tumor enucleation for solid pseudopapillary neoplasms in children: A retrospective case series
Main Article Content
Abstract
This retrospective study evaluated the short-term outcomes of pancreatic head tumor resection in 14 pediatric patients with solid pseudopapillary neoplasm (SPN) treated at the Vietnam National Children’s Hospital between January 2022 and December 2024. The mean age at diagnosis was 10.5 years old (range, 7 - 15), with a female predominance (78.6%). The most common presenting symptom was epigastric and left hypochondrial pain (85.7%), and the mean tumor size was 4.6cm (range, 1.9 - 10cm). On computed tomography, the majority of tumors exhibited a mixed solid-cystic pattern (64.3%). All patients underwent pancreatic head resection without perioperative mortality. Postoperative complications included pancreatic fistula (7.1%) and biliary fistula (7.1%). One patient developed recurrence at 14 months, while the remaining cases remained in stable condition under regular follow-up. These findings suggest that SPN of the pancreas is a rare, low-grade malignant tumor, and pancreatic head-preserving resection is a safe and effective treatment in children, with low rates of complications and recurrence.
Article Details
Keywords
Solid pseudopapillary neoplasm of the pancreas, children, pancreatic head tumor enucleation
References
2. Jentzsch C, Fuchs J, Agaimy A, et al. Solid pseudopapillary neoplasms of the pancreas in childhood and adolescence-an analysis of the German Registry for Rare Pediatric Tumors (STEP). Eur J Pediatr. 2023; 182(12): 5341-5352. doi:10.1007/s00431-023-05203-w.
3. Naar L, Spanomichou DA, Mastoraki A, Smyrniotis V, Arkadopoulos N. Solid Pseudopapillary Neoplasms of the Pancreas: A Surgical and Genetic Enigma. World J Surg. 2017; 41(7): 1. doi:10.1007/s00268-017-3921-y.
4. Yepuri N, Naous R, Meier AH, et al. A systematic review and meta-analysis of predictors of recurrence in patients with Solid Pseudopapillary Tumors of the Pancreas. HPB. 2020; 22(1): 12-19. doi:10.1016/j.hpb.2019.06.005.
5. Maimaijiang A, Wang H, Li W, Wang Y. Diagnosis and treatment of solid pseudopapillary neoplasm of the pancreas in children: A report of 18 cases. Front Pediatr. 2022; 10:899965. doi:10.3389/fped.2022.899965.
6. Bochis OV, Bota M, Mihut E, Buiga R, Hazbei DS, Irimie A. Solid pseudopapillary tumor of the pancreas: clinical-pathological features and management of 13 cases. Clujul Med 1957. 2017; 90(2): 171-178. doi:10.15386/cjmed-672.
7. Kumar NAN, Bhandare MS, Chaudhari V, Sasi SP, Shrikhande SV. Analysis of 50 cases of solid pseudopapillary tumor of pancreas: Aggressive surgical resection provides excellent outcomes. Eur J Surg Oncol J Eur Soc Surg Oncol Br Assoc Surg Oncol. 2019; 45(2): 187-191. doi:10.1016/j.ejso.2018.08.027.
8. Ahmad NA, Kochman ML, Brensinger C, et al. Interobserver agreement among endosonographers for the diagnosis of neoplastic versus non-neoplastic pancreatic cystic lesions. GastrointestEndosc. 2003; 58(1): 59-64. doi:10.1067/mge.2003.298.
9. Shen Y, Wang Z, Zhu J, Chen Y, Gu W, Liu Q. α-Methylacyl-CoA racemase (P504S) is a useful marker for the differential diagnosis of solid pseudopapillary neoplasm of the pancreas. Ann Diagn Pathol. 2014; 18(3): 146-150. doi:10.1016/j.anndiagpath.2014.02.006.
10. You L, Yang F, Fu DL. Prediction of malignancy and adverse outcome of solid pseudopapillary tumor of the pancreas. World J Gastrointest Oncol. 2018; 10(7): 184-193. doi:10.4251/wjgo.v10.i7.184.
11. Wang X, Chen YH, Tan CL, et al. Enucleation of pancreatic solid pseudopapillary neoplasm: Short-term and long-term outcomes from a 7-year large single-center experience. Eur J Surg Oncol J Eur Soc Surg Oncol Br Assoc Surg Oncol. 2018; 44(5): 644-650. doi:10.1016/j.ejso.2018.01.085.
12. Xu YC, Fu DL, Yang F. Unraveling the enigma: A comprehensive review of solid pseudopapillary tumor of the pancreas. World J Gastrointest Oncol. 2024; 16(3): 614-629. doi:10.4251/wjgo.v16.i3.614.
13. Beger HG, Nakao A, Mayer B, Poch B. Duodenum-preserving total and partial pancreatic head resection for benign tumors - Systematic review and meta-analysis. Pancreatology. 2015; 15(2): 167-178. doi:10.1016/j.pan.2015.01.009.
14. Kato T, Egawa N, Kamisawa T, et al. A case of solid pseudopapillary neoplasm of the pancreas and tumor doubling time. Pancreatology. 2002; 2(5): 495-498. doi:10.1159/000064711.
15. Lin MYC, Stabile BE. Solid Pseudopapillary Neoplasm of the Pancreas: A Rare and Atypically Aggressive Disease among Male Patients. Am Surg. 2010; 76(10): 1075-1078. doi:10.1177/000313481007601011.