20. Association between the neutrophil-to-lymphocyte ratio and mortality in pediatric sepsis
Main Article Content
Abstract
This study investigated the association between the neutrophil to lymphocyte ratio (NLR) and mortality in children with sepsis. A prospective case series was conducted on 101 children diagnosed with sepsis in the Pediatric Intensive Care Unit, Vietnam National Children’s Hospital, from September 2024 to June 2025. The median age of the patients was 15.1 months old; 62.4% were male, and 19.8% had underlying diseases. Case fatality was 24.8%. The non-survivors had higher PRISM III scores, PELOD II scores, NLR on day 3, and NLR on day 5 compared to the survivors (p < 0.001; < 0.001; 0.03 and < 0.001, respectively). NLR within the first 24 hours showed no statistically significant difference between the survival and mortality groups (p = 0.75). Multivariate logistic regression analysis showed that PRISM III (OR = 1.7; 95% CI: 1.3 - 2.2; p < 0.001) and NLR on day 5 (OR = 1.3; 95% CI: 1.0 - 1.6; p = 0.023) were independent predictors of mortality. NLR on day 5 had an area under the ROC curve (AUC) of 0.833 (95% CI: 0,73 - 0.93; p < 0.001) with a cut-off value of 2.73 (sensitivity 92%, specificity 65.8%), indicating good prognostic accuracy.
Article Details
Keywords
NLR, pediatric sepsis, mortality risk
References
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