17. Giá trị một số xét nghiệm thường quy trong tiên lượng sớm kết quả điều trị suy gan cấp ở trẻ em

Abstract

Acute liver failure (ALF) in children remains a major challenge in pediatrics due to its rapid progression and high mortality risk. The use of routine laboratory tests in the evaluation and prognosis of pediatric ALF has high practical value in clinical practice, allowing clinicians to formulate effective treatment strategies. A descriptive study on 137 children with ALF at the National Children’s Hospital from June 2020 to June 2025 was conducted to assess the role of several routine laboratory tests in the early prediction of treatment outcomes in pediatric ALF. The overall treatment success rate in the study cohort was 68%. The results showed that several factors associated with poor prognosis and mortality included anemia, platelet count < 50 G/L, fibrinogen < 1 g/L, elevated INR (AUC = 0.756, p < 0.01), and total bilirubin. However, no association was found between albumin, glucose, GOT, GPT, and GGT with treatment outcomes. In conclusion, several routine laboratory tests within the first 7 days after diagnosis, particularly INR ≥ 4.48, played an important prognostic role in treatment outcomes of pediatric ALF, contributing to the early identification of high-risk patients and guiding effective treatment.