Article Sidebar

PDF (Tiếng Việt)
Published: 2021-10-30
Abstract Views: 817
Views PDF (Tiếng Việt): 1252
DOI: https://doi.org/10.52852/tcncyh.v145i9.419
Issue
Vol. 145 No. 9 (2021)
Section
Các bài báo
How to Cite
Tran, Q. K., Thúy, N. T. D., & Hùng, T. Đỗ. (2021). The isolation rate and the level of antibiotic resistance of streptococcus pneumoniae in children with severe pneumonia in Can Tho . Journal of Medical Research, 145(9), 229-240. https://doi.org/10.52852/tcncyh.v145i9.419

The isolation rate and the level of antibiotic resistance of streptococcus pneumoniae in children with severe pneumonia in Can Tho

Quang Khai Tran, Nguyễn Thị Diệu Thúy, Trần Đỗ Hùng

Main Article Content

Abstract

Streptococcus pneumoniae is the most common bacteria causing community - acquired pneumonia (CAP) in children. The rate of S. pneumoniae resistant to antibiotics is increasing, especially in severe CAP. The isolation rate and the level of antibiotic resistance of S. pneumonniae causing severe CAP in children in Can Tho need updating. Nasopharyngeal aspiration specimens in children were cultured, isolated and identified for S. pneumoniaeassessed for antimicrobial susceptibility testing and determined for minimum inhibitory concentration (MIC). 89 strains of S. pneumoniae were isolated from 239 severe CAP children. Bacteria were completely non - susceptible to penicillin with MIC90 at 64 mg/L, 8 times higher than the resistance threshold according to CLSI (2017); highly resistant to erythromycin (96.6%), trimethoprim/sulfamethoxazole (89.9%), clindamycin and clarithromycin (together 88.8%); susceptible to chloramphenicol, levofloxacin, ciprofloxacin and ceftriaxone were 94.4%, 80.9%, 59.6% and 46.1%, respectively; 100% of strains were susceptible to vancomycin and linezolid. Therefore, the first choice of antibiotics should be ceftriaxone. Alternative antibiotics could be levofloxacin, vancomycin and linezolid.

Article Details

Keywords

Streptococcus pneumoniae, antibiotics resistance, severe pneumonia, children, Can Tho

References

1. GBD 2016 Lower Respiratory Infections Collaborators. Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory infections in 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. The Lancet Infectious diseases. 2018;18(11):1191-1210.
2. Marangu D, Zar HJ. Childhood pneumonia in low-and-middle-income countries: An update. Paediatric respiratory reviews. 2019;32:3-9.
3. Wahl B, O'Brien KL, Greenbaum A, et al. Burden of Streptococcus pneumoniae and Haemophilus influenzae type b disease in children in the era of conjugate vaccines: global, regional, and national estimates for 2000-15. The Lancet Global health. 2018;6(7):e744-e757.
4. Lee JK, Yun KW, Choi EH, Kim SJ, Lee SY, Lee HJ. Changes in the Serotype Distribution among Antibiotic Resistant Carriage Streptococcus pneumoniae Isolates in Children after the Introduction of the Extended-Valency Pneumococcal Conjugate Vaccine. Journal of Korean medical science. 2017;32(9):1431-1439.
5. Beheshti M, Jabalameli F, Feizabadi MM, Hahsemi FB, Beigverdi R, Emaneini M. Molecular characterization, antibiotic resistance pattern and capsular types of invasive Streptococcus pneumoniae isolated from clinical samples in Tehran, Iran. BMC microbiology. 2020;20(1):167.
6. WHO. Pocket book of Hospital care for children - Guidelines for the Management of common childhood illnesses. 2nd ed. Geneva: World Health Organization; 2013.
7. Harris M, Clark J, Coote N, et al. British Thoracic Society guidelines for the management of community acquired pneumonia in children: update 2011. Thorax. 2011;66 Suppl 2:ii1-23.
8. Nguyễn Phước Hưng. Khảo sát nồng độ procalcitonin máu ở trẻ từ 2 tháng đến 15 tuổi bị viêm phổi tại bệnh viện Đa khoa Đồng Tháp. Tạp chí Y học Thành phố Hồ Chí Minh. 2016;20(1):31-36.
9. Murdoch DR, Morpeth SC, Hammitt LL, et al. Microscopic Analysis and Quality Assessment of Induced Sputum From Children With Pneumonia in the PERCH Study. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2017;64(suppl_3):S271-s279.
10. Clinical and Laboratory Standards Institute (CLSI). Performance Standards for Antimicrobial Susceptibility Testing. In: CLSI supplement M100. 27th ed. Wayne, PA: Clinical and Laboratory Standards Institute; 2017.
11. Sweeney MT, Lubbers BV, Schwarz S, Watts JL. Applying definitions for multidrug resistance, extensive drug resistance and pandrug resistance to clinically significant livestock and companion animal bacterial pathogens. Journal of Antimicrobial Chemotherapy. 2018;73(6):1460-1463.
12. Larsson M, Nguyen HQ, Olson L, Tran TK, Nguyen TV, Nguyen CTK. Multi-drug resistance in Streptococcus pneumoniae among children in rural Vietnam more than doubled from 1999 to 2014. Acta paediatrica (Oslo, Norway : 1992). 2021.
13. Shah SN, Bachur RG, Simel DL, Neuman MI. Does This Child Have Pneumonia?: The Rational Clinical Examination Systematic Review. Jama. 2017;318(5):462-471.
14. Williams DJ, Zhu Y, Grijalva CG, et al. Predicting Severe Pneumonia Outcomes in Children. Pediatrics. 2016;138(4):e20161019. doi: 20161010.20161542/peds.20162016-20161019.
15. Williams DJ, Edwards KM, Self WH, et al. Effectiveness of β-Lactam Monotherapy vs Macrolide Combination Therapy for Children Hospitalized With Pneumonia. JAMA pediatrics. 2017;171(12):1184-1191.
16. Al Saeedy D, Gillani SW, Al-Salloum J, Moosvi A, Eissa M, Gulam SM. Comparative Efficacy of Beta-Lactams and Macrolides in the Treatment of Pediatric Pneumonia: a Systematic Review. Current pediatric reviews. 2020.
17. El-Kholy A, Badawy M, Gad M, Soliman M. Serotypes and Antimicrobial Susceptibility of Nasopharyngeal Isolates of Streptococcus pneumoniae from Children Less Than 5 Years Old in Egypt. Infection and drug resistance. 2020;13:3669-3677.