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Published: 2021-10-30
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DOI: https://doi.org/10.52852/tcncyh.v145i9.419
Issue
Vol. 145 No. 9 (2021)
Section
Các bài báo
How to Cite
Tran, Q. K., Thúy, N. T. D., & Hùng, T. Đỗ. (2021). The isolation rate and the level of antibiotic resistance of streptococcus pneumoniae in children with severe pneumonia in Can Tho . Journal of Medical Research, 145(9), 229-240. https://doi.org/10.52852/tcncyh.v145i9.419

The isolation rate and the level of antibiotic resistance of streptococcus pneumoniae in children with severe pneumonia in Can Tho

Quang Khai Tran, Nguyễn Thị Diệu Thúy, Trần Đỗ Hùng

Main Article Content

Abstract

Streptococcus pneumoniae is the most common bacteria causing community - acquired pneumonia (CAP) in children. The rate of S. pneumoniae resistant to antibiotics is increasing, especially in severe CAP. The isolation rate and the level of antibiotic resistance of S. pneumonniae causing severe CAP in children in Can Tho need updating. Nasopharyngeal aspiration specimens in children were cultured, isolated and identified for S. pneumoniaeassessed for antimicrobial susceptibility testing and determined for minimum inhibitory concentration (MIC). 89 strains of S. pneumoniae were isolated from 239 severe CAP children. Bacteria were completely non - susceptible to penicillin with MIC90 at 64 mg/L, 8 times higher than the resistance threshold according to CLSI (2017); highly resistant to erythromycin (96.6%), trimethoprim/sulfamethoxazole (89.9%), clindamycin and clarithromycin (together 88.8%); susceptible to chloramphenicol, levofloxacin, ciprofloxacin and ceftriaxone were 94.4%, 80.9%, 59.6% and 46.1%, respectively; 100% of strains were susceptible to vancomycin and linezolid. Therefore, the first choice of antibiotics should be ceftriaxone. Alternative antibiotics could be levofloxacin, vancomycin and linezolid.

Article Details

Keywords

Streptococcus pneumoniae, antibiotics resistance, severe pneumonia, children, Can Tho

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