Đa hình rs1260326 gen GCKR và đường huyết lúc đói ở người bệnh gút Việt Nam: Nghiên cứu thăm dò

Abstract

Gout is a metabolic disorder frequently associated with metabolic comorbidities and hyperglycemia, in which the GCKR rs1260326 polymorphism has been implicated as a relevant genetic factor. We enrolled 45 Vietnamese patients with gout, performed genotyping for rs1260326, and measured fasting plasma glucose (FPG). Mean FPG levels were compared between genotype groups (CC vs. CT+TT) and alleles (C vs. T) after adjustment for covariates, including age, sex, and body mass index. The statistical significance threshold was subsequently corrected using the false discovery rate (FDR) method. The results showed that patients carrying the CC genotype had significantly higher mean FPG than those carrying the T allele (CT+TT) (pFDR < 0.05). Similarly, the C allele was associated with higher FPG levels compared with the T allele (pFDR < 0.05). Conclusion: Preliminary findings suggest that the GCKR rs1260326 polymorphism is associated with fasting hyperglycemia, potentially contributing to the metabolic comorbidities observed in patients with gout.