Association between PDZK1 rs12129861 polymorphism and serum uric acid levels in patients with newly diagnosed gout: Preliminary data from Vietnam
Main Article Content
Abstract
Gout is a prevalent disorder of purine metabolism, in which the PDZK1 rs12129861 polymorphism has been documented to influence uric acid concentrations. However, data regarding the Vietnamese population remain limited. A cross-sectional descriptive study was conducted on 49 patients with newly diagnosed gout at Dong Nai General Hospital. Genotyping of the PDZK1 rs12129861 polymorphism was performed using Real-time PCR assay. Multivariate linear regression analysis was employed to identify factors independently associated with uric acid levels, with adjustments applied using the Benjamini-Hochberg method in R software version 4.5.0. The results indicated an increasing trend in uric acid levels across the CC, CT, and TT genotypes, although statistical significance was not reached. The T allele was independently associated with elevated serum uric acid, with a mean increase of 47.1 µmol/L (95% CI: 13.4 – 80.8). Female gender was independently associated with lower uric acid concentrations. Preliminary findings suggest that the PDZK1 rs12129861 polymorphism plays a role in regulating uric acid levels in Vietnamese patients with gout.
Article Details
Keywords
rs12129861, PDZK1, gout, uric acid, preliminary data
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