Study on subgenotypes of Enterovirus A71 circulated in Dak Lak in 2023
Main Article Content
Abstract
Enterovirus A71 (EV-A71) is a principal etiological agent of hand, foot and mouth disease (HFMD) and is causing severe neurological complications. A cross-sectional study to determine subgenotypes and characterize their molecular features of EV-A71 strains isolated in Dak Lak in 2023. The results showed that two EV-A71 subgenotypes, C4 and B5, were identified as circulating in Dak Lak in 2023. Subgenotype B5 predominated, accounting for 88.90% of isolates, whereas subgenotype C4 accounted for 11.10%. Among B5 strains, nucleotide sequence identity ranged from 99.10% to 100%, and amino acid sequence identity ranged from 97.64% to 100%. Phylogenetic analysis demonstrated that B5 strains circulating in Dak Lak were genetically closely related to B5 strains circulating in Ho Chi Minh City in 2023. The high nucleotide and amino acid sequence homology among EV-A71 strains underscores their significance in the epidemiology of HFMD in Dak Lak in 2023. These findings provide critical evidence for molecular surveillance, particularly enabling the early detection of subgenotype replacement and the emergence of novel variants with epidemic potential. Such insights enhance the capacity to predict outbreak risks and provide the development and timely implementation of proactive and effective strategies for the prevention and control of hand, foot, and mouth disease in the future.
Article Details
Keywords
Hand, foot, and mouth disease, Enterovirus A71, Dak Lak
References
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