Đa hình rs2070744 gen NOS3 và mối liên quan với biến chứng não ở bệnh nhân tăng huyết áp

Abstract

Several studies have suggested an association between the rs2070744 polymorphism of the NOS3 gene and cerebrovascular complications in patients with hypertension.However, this association has not yet been investigated in the Vietnamese population. This analytical cross-sectional study was conducted in 96 hypertensive patients at Can Tho Cardiovascular Hospital to examine the association between the rs2070744 polymorphism and cerebrovascular complications. The prevalence of stroke or transient ischemic attack was 21.9%. The TT genotype was the most frequent genotype (73.5%), followed by CT (21.0%). Carriers of the C allele (CC + CT) had higher odds of cerebrovascular complications than patients with the TT genotype (OR = 5.77; p = 0.001). Similarly, the C allele was associated with increased odds of cerebrovascular complications (OR = 4.55; p = 0.001). After adjustment for potential confounders, these associations remained statistically significant for C-allele carriers (CC + CT) (OR = 5.57; p = 0.002) and for the C allele (OR = 4.18; p < 0.001). In conclusion, the rs2070744 polymorphism of the NOS3 gene, particularly the C allele, may serve as a potential genetic marker for cerebrovascular risk stratification in hypertensive patients.