Đánh giá độc tính của siro Liver Zen trên động vật thực nghiệm

Abstract

Liver Zen syrup is formulated from various herbal ingredients and is intended for supportive treatment of liver diseases such as hepatitis and liver dysfunction. This study aimed to evaluate the acute and subchronic toxicity of the preparation in Swiss mice. In the acute toxicity test, mice were administered Liver Zen syrup at increasing doses to determine the safety threshold. The results showed that at the maximum tolerable oral dose of 100 mL/kg, no sign of toxicity was observed and no mortality occurred. In the subchronic toxicity study, mice were divided into a control group and two treatment groups receiving 9.6 and 28.8 mL/kg/day, respectively, for four weeks. Parameters monitored included general condition, body weight, hematological and biochemical indices, as well as gross and histopathological examination of the liver and kidneys. The findings indicated that AST and ALT levels in the treated groups decreased compared to the control group, while other parameters showed no significant differences. These results suggest that Liver Zen syrup does not induce acute or subchronic toxicity in Swiss mice at the tested dose levels.