Đặc điểm tổn thương tế bào máu ngoại vi ở người bệnh lupus ban đỏ hệ thống điều trị nội trú tại Bệnh viện Bạch Mai

Abstract

This cross-sectional descriptive study included 50 hospitalized patients with systemic lupus erythematosus (SLE) at the Center for Allergy and Clinical Immunology, Bach Mai Hospital. The study aimed to describe peripheral blood cell abnormalities and explore their associations with selected clinical manifestations and disease activity. All patients fulfilled the 2019 EULAR/ACR classification criteria for SLE and had at least one complete blood count abnormality. Female patients accounted for 90% of the cohort, and renal-urinary involvement was the most frequent clinical manifestation (82%). Most patients had high or very high disease activity according to SLEDAI-2K. In this selected inpatient cohort, anemia was the most common abnormality (92%), mainly mild to moderate, with normocytic normochromic anemia accounting for 67.4%. Lymphopenia and thrombocytopenia were observed in 38% and 16% of patients, respectively. Renal-urinary involvement was associated with lower red blood cell counts and hemoglobin levels, while neuropsychiatric manifestations were associated with lower platelet counts. Patients with high or very high disease activity had lower red blood cell counts, hemoglobin levels, and platelet counts than those with mild or moderate activity. Complete blood count may provide supportive information for assessing and monitoring hospitalized patients with SLE.