Asymptomatic hyperuricemia and associated factors in male patients at Hanoi Medical University Hospital

Tú Phạm, Phạm Thu Hằng, Đỗ Thị Huyền Trang, Trần Thu Giang, Nguyễn Thị Thoa, Phạm Hoài Thu

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Abstract

To evaluate asymptomatic hyperuricemia and associated factors in male, we studied 798 male patients who visited Hanoi Medical University Hospital from January 2020 to May 2021. A cross-sectional descriptive study was applied. Results shown that the rate of asymptomatic hyperuricemia was 41.4%, the average uric acid concentration in plasma was 405.2 ± 81.2 µmol/l (maximum: 820 µmol/l). Asymptomatic hyperuricemia was the most common in men aged 40 to 59 years (accounting for 48.3%). Alcohol consumption, hypertension, overweight/ obesity, dyslipidemia are risk factors for hyperuricemia (with p value < 0.05). There was a positive correlation between uric acid level and total cholesterol, triglyceride concentration in blood (with p value < 0.05). The state of asymptomatic hyperuricemia in men was elevated, especially in those with dyslipidemia, hypertension and alcohol consumption.

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References

1. Bursill D, Taylor WJ, Terkeltaub R, et al. Gout, Hyperuricemia, and Crystal-Associated Disease Network Consensus Statement Regarding Labels and Definitions for Disease Elements in Gout. Arthritis Care Res. 2019;71(3):427-434. doi:10.1002/acr.23607.
2. George C, Minter DA. Hyperuricemia. In: StatPearls. StatPearls Publishing; 2021. Accessed July 14, 2021. http://www.ncbi.nlm.nih.gov/books/NBK459218/.
3. Zhu Y, Pandya BJ, Choi HK. Prevalence of gout and hyperuricemia in the US general population: the National Health and Nutrition Examination Survey 2007-2008. Arthritis Rheum. 2011;63(10):3136-3141. doi:10.1002/art.30520.
4. Ni Q, Lu X, Chen C, et al. Risk factors for the development of hyperuricemia: A STROBE-compliant cross-sectional and longitudinal study. Medicine (Baltimore). 2019;98(42):e17597. doi:10.1097/MD.0000000000017597.
5. Trịnh Kiến Trung. Nghiên cứu nồng độ acid uric máu, bệnh Gout và hội chứng chuyển hóa ở người từ 40 tuổi trở lên tại thành phố Cần Thơ. Học Viên Quân. 2015;Luận văn Tiến sĩ y học.
6. Phạm Thị Dung, Lê Bạch Mai. Một số yếu tố liên quan đến tăng acid uric huyết thanh ở người trưởng thành nông thôn Thái Bình. Tạp chí Y học Dự phòng. 2014; XXIV,số 8 (157): 37- 41.
7. Raja S, Kumar A, Aahooja RD, et al. Frequency of Hyperuricemia and its Risk Factors in the Adult Population. Cureus. 11(3):e4198. doi:10.7759/cureus.4198.
8. Lin X, Wang X, Li X, et al. Gender- and Age-Specific Differences in the Association of Hyperuricemia and Hypertension: A Cross-Sectional Study. Int J Endocrinol. 2019; 2019:7545137. doi:10.1155/2019/7545137.
9. Song P, Wang H, Xia W, et al. Prevalence and correlates of hyperuricemia in the middle-aged and older adults in China. Sci Rep. 2018; 8(1):4314. doi:10.1038/s41598-018-22570-9.
10. WANG H, WANG L, XIE R, et al. Association of Serum Uric Acid with Body Mass Index: A Cross-Sectional Study from Jiangsu Province, China. Iran J Public Health. 2014; 43(11):1503-1509.
11. Becker MA, Jolly M. Hyperuricemia and associated diseases. Rheum Dis Clin North Am. 2006; 32(2):275-293, v-vi. doi:10.1016/j.rdc.2006.02.005.
12. Liu F, Du G-L, Song N, et al. Hyperuricemia and its association with adiposity and dyslipidemia in Northwest China: results from cardiovascular risk survey in Xinjiang (CRS 2008–2012). Lipids Health Dis. 2020; 19(1):58. doi:10.1186/s12944-020-01211-z.