Pain management and adverse effects of patient-controlled morphine and pethidine for postoperative cardiac surgery
Main Article Content
Abstract
This study was to compare the analgesic effect and side effects of patient- controlled analgesia device with the different regiment of morphine and pethidine after cardiac surgery. This is a prospective, randomized, and single-blinded study performed at The Cardiovascular center of E Hospital. Fifty patients undergoing cardiopulmonary bypass surgery were included in the study. After extubation, participants were randomized into 2 groups of 25 patients each. Groups M w was given morphine (bolus dose 1mg, lockout 5 minutes, limit 20mg/4h) and group P was given pethidine (bolus dose 25mg, lockout 5 minutes, limit 150mg/4h). Pain was assessed by using a visual analog scale (0 - 10), and sedation was assessed with the Ramsay sedation score (1-6) in the first 3 days after extubation. VAS at rest of group P was lower than group M, (0.36 ± 0.57) versus (1.16 ± 0.9) p < 0.01 at day 2 postoperatively; VAS score at movement and side effects such as nausea, vomiting and urinary retention were similar between the two groups. However, group P had a lower sedation score than group M at 0.32 (95% CI= -0.51; -0.12, p < 0.01).
Article Details
Keywords
Patient-controlled analgesia, opioids, pain management after cardiac surgery
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