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Published: 2022-02-22
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DOI: https://doi.org/10.52852/tcncyh.v150i2.728
Issue
Vol. 150 No. 2 (2022)
Section
Các bài báo
How to Cite
Nhi, P. T. U. ., Thường, N. V., Hào, N. T., Vũ, H. A., & Trâm, D. B. (2022). Association between single nucleotide polymorphisms IL-17F RS763780, IL-17RA RS4819554 AND HLA-CW6 and psoriasis vulgaris in Vietnam. Journal of Medical Research, 150(2), 1-13. https://doi.org/10.52852/tcncyh.v150i2.728

Association between single nucleotide polymorphisms IL-17F RS763780, IL-17RA RS4819554 AND HLA-CW6 and psoriasis vulgaris in Vietnam

Pham Thi Uyen Nhi, Nguyen Van Thuong, Nguyen Trong Hao, Hoang Anh Vu, Duong Bich Tram

Main Article Content

Abstract

Psoriasis is a chronic recurrent inflammatory disease where genetic factors contribute 3% of the disease's pathogenesis; as such, the identification of biological markers is an important role in the prediction of treatment response and prognosis. This study determines basic characteristics in Vietnamese psoriasis vulgaris patients, prevalence and genotype of IL-17F RS763780, IL17RA rs4819554, and HLA-Cw6.  Blood test was performed on 121 samples, then DNA and genotype achieved by CLC Main Workbench software. Mean severity is 20,31 ± 12,70 and PASI is 14,88 ± 7,59. Genotype distribution is different in every position. Gene IL-17F rs763780 has the highest AA in psoriasis patients with 58.7%, GA takes 38.0%. Gene IL-17RA rs4819554 has 53.7% GA and 27.3%AA. 35.04% patients are HLA-Cw6 negative and 64.96% are positive. Patients with positive HLA-Cw6 have 77.63% heterozygous, and 22.37% homozygous. There is no correlation among HLA-Cw6, SNP IL-17F RS763780 and IL17RA rs4819554. However, there is the correlation between IL-17F RS763780 and the severity of psoriasis.

Article Details

Keywords

Single-nucleotide polymorphism, IL17RA, rs4819554, RS763780, HLA-Cw6, psoriasis vulgaris

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