8. The relationship between clinical, labotatory and kidney injury on renal biopsy in children with proliferative lupus nephritis
Main Article Content
Abstract
Lupus nephritis (LN) is a serious complication of systemic lupus erythematosus (SLE). A cross-sectional descriptive study was carried out on 73 new LN children (79.2% female and 20.8% male) diagnosed for proliferative LN (46.6% class III and 53.4% class IV) by kidney biopsy. Mean age was 10.86 years. The purpose of this study was to evaluate the relationship between clinical, laboratory and kidney injury on renal biopsy in children with proliferative lupus nephritis. The common symptoms were skin lesions (82.2%), anemia (72.6%), edema (65.8%), hematuria (65.8%), arthritis (43.8%) and hypertension (27.4%). Edema and hypertension were more common in class IV LN group than class III. 69.9% of patients had proteinuria in the nephrotic range, 50.7% had nephrotic syndrome. 37.7% of patients had decreased estimated glomerular filtration rate (eGFR). eGFR < 90 ml/minus/1.73m2 and proteinuria at the nephrotic range increased the risk of having LN class IV with OR of 3.79 and 4.889, respectively (p < 0.01). Most children had SLE disease activity index scores in high and very high activity (74% and 9.6% respectively). There was no difference between class III and IV LN.
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Keywords
Proliferative lupus nephritis, clinical, laboratory, renal biopsy
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