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Published: 2022-06-15
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DOI: https://doi.org/10.52852/tcncyh.v155i7.849
Issue
Vol. 155 No. 7 (2022)
Section
Các bài báo
How to Cite
Hằng, Đào V. ., Vựng, V. T. ., Long, H. B. ., Oanh, T. T. ., Trang, T. T. T. ., Sa, N. V. ., & Long, Đào V. . (2022). 7. Effectiveness of Immunoglobulin Y and Lactobacillus johnsonii in supporting the treatment of peptic ulcer disease with Helicobacter pylori. Journal of Medical Research, 155(7), 43-52. https://doi.org/10.52852/tcncyh.v155i7.849

7. Effectiveness of Immunoglobulin Y and Lactobacillus johnsonii in supporting the treatment of peptic ulcer disease with Helicobacter pylori

Dao Viet Hang, Vu Thi Vung, Hoang Bao Long, Trinh Thi Oanh, Tran Thi Thu Trang, Nguyen Van Sa, Dao Van Long

Main Article Content

Abstract

A double-blind, randomized, placebo-controlled trial was conducted to evaluate the success rate of Helicobacter pylori (H. pylori) eradication, improvement of clinical symptoms, and safety of a product containing immunoglobin Y and Lactobacillus johnsonii in supporting the quadruple regime for H. pylori infection treatment. The H. pylori eradication success was ascertained by the C14 Helicobacter breath test 4 weeks after stopping the medications. A total of 190 patients were randomized. Though the success rate of H. pylori eradication was higher in the intervention group (87.5%) than the controls (84.9%), the difference was not statistically significant (RR = 1.03; 95%CI: 0.88 - 1.20). Between two groups, the percentage of patients who had symptoms at follow up was not statistically different. Adverse events after two weeks using the product included fatigue, altered sense of taste, nausea, diarrhea, and bloating. Our study suggested that a product containing immunoglobin Y and Lactobacillus johnsonii was safe and could be beneficial in supporting the treatment of H. pylori infection; however, clinical trials with larger sample size are needed to confirm the effectiveness of this product.

Article Details

Keywords

Lactobacillus johnsonii, IgY, Helicobacter pylori, peptic ulcer, eradication therapy

References

1. Yang JC, Lin CJ, Wang HL, et al. High-dose dual therapy is superior to standard first-line or rescue therapy for Helicobacter pylori infection. Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc. 2015;13(5):895-905.e5. doi: 10.1016/j.cgh.2014.10.036.
2. Khien VV, Thang DM, Hai TM, et al. Management of antibiotic-resistant Helicobacter pylori infection: Perspectives from Vietnam. Gut Liver. 2019;13(5):483-497. doi: 10.5009/gnl18137.
3. Chey W, Leontiadis G, Howden C, F Moss S. ACG Clinical guideline: Treatment of Helicobacter pylori infection. Vol 112.;2017. doi: 10.1038/ajg.2016.563.
4. Katelaris P, Hunt R, Bazzoli F, et al. World gastroenterology organisation global guidelines. 2021.
5. Kafshdooz T, Akbarzadeh A, Majdi Seghinsara A, Pourhassan M, Nasrabadi HT, Milani M. Role of probiotics in managing of Helicobacter pylori infection: A Review. Drug Res Stuttg. 2017;67(2):88-93. doi: 10.1055/s-0042-116441.
6. Mony TJ, Kwon HS, Won MK, et al. Anti-urease immunoglobulin (IgY) from egg yolk prevents Helicobacter pylori infection in a mouse model. Food Agric Immunol. 2019;30(1):662-676. doi: 10.1080/09540105.2019.1617251.
7. Khiên VVK. Hiệu quả điều trị hỗ trợ của OvalgenHP ở bệnh nhân viêm dạ dày mạn, loét dạ dày - tá tràng nhiễm Helicobacter pylori. 2016.
8. Aiba Y, Umeda K, Rahman S, Nguyen SV, Komatsu Y. Synergistic effect of anti-Helicobacter pylori urease immunoglobulin Y from egg yolk of immunized hens and Lactobacillus johnsonii No.1088 to inhibit the growth of Helicobacter pylori in vitro and in vivo. Vaccine. 2019;37(23):3106-3112. doi: 10.1016/j.vaccine.2019.04.045.
9. Hội Tiêu hoá Việt Nam. Khuyến cáo chẩn đoán và điều trị Helicobacter pylori tại Việt Nam. 2013.
10. Trần Thị Khánh Tường, và cs. Hiệu quả điều trị của phác đồ 4 thuốc có bismuth trong điều trị nhiễm Helicobacter pylori. Tạp chí Dược học. 2017;7:29-34.
11. Horie K, Horie N, Abdou AM, et al. Suppressive effect of functional drinking yogurt containing specific egg yolk immunoglobulin on Helicobacter pylori in humans. J Dairy Sci. 2004;87(12):4073-4079. doi: 10.3168/jds.S002 2-0302(04)73549-3.
12. Yang YH, Park D, Yang G, et al. Anti-Helicobacter pylori effects of IgY from egg york of immunized hens. Lab Anim Res. 2012;28(1):55-60. doi: 10.5625/lar.2012.28.1.55.
13. Suzuki H, Nomura S, Masaoka T, et al. Effect of dietary anti-Helicobacter pylori-urease immunoglobulin Y on Helicobacter pylori infection. Aliment Pharmacol Ther. 2004;20 Suppl 1:185-192. doi: 10.1111/j.1365-2036.2004.02027.x.
14. Wang ZH, Gao QY, Fang JY. Meta-analysis of the efficacy and safety of Lactobacillus-containing and Bifidobacterium-containing probiotic compound preparation in Helicobacter pylori eradication therapy. J Clin Gastroenterol. 2013;47(1):25-32. doi: 10.1097/MCG.0b013e318266f6cf.
15. Zhang MM, Qian W, Qin YY, He J, Zhou YH. Probiotics in Helicobacter pylori eradication therapy: a systematic review and meta-analysis. World J Gastroenterol. 2015;21(14):4345-4357. doi: 10.3748/wjg.v21.i14.4345.
16. Gong Y, Li Y, Sun Q. Probiotics improve efficacy and tolerability of triple therapy to eradicate Helicobacter pylori: a meta-analysis of randomized controlled trials. Int J Clin Exp Med. 2015;8(4):6530-6543.
17. Lu C, Sang J, He H, et al. Probiotic supplementation does not improve eradication rate of Helicobacter pylori infection compared to placebo based on standard therapy: a meta-analysis. Sci Rep. 2016;6(1):23522. doi: 10.1038/srep23522.
18. Aiba Y, Nakano Y, Koga Y, Takahashi K, Komatsu Y. A highly acid-resistant novel strain of Lactobacillus johnsonii No. 1088 has antibacterial activity, including that against Helicobacter pylori, and inhibits gastrin-mediated acid production in mice. Microbiologyopen. 2015;4(3):465-474. doi: 10. 1002/mbo3.252.
19. Malfertheiner P, Megraud F, O’Morain CA, et al. Management of Helicobacter pylori infection-the maastricht V/Florence consensus report. Gut. 2017;66(1):6-30. doi: 10.1136/gutj nl-2016-312288.
20. Zheng X, Lyu L, Mei Z. Lactobacillus-containing probiotic supplementation increases Helicobacter pylori eradication rate: evidence from a meta-analysis. Rev Espanola Enfermedades Dig Organo Of Soc Espanola Patol Dig. 2013;105(8):445-453. doi: 10.4321/s 1130-01082013000800002.
21. Russo M, Nahori MA, Lefort J, et al. Suppression of asthma-like responses in different mouse strains by oral tolerance. Am J Respir Cell Mol Biol. 2001;24(5):518-526. doi: 10.1165/ajrcmb.24.5.4320.
22. Losonsky GA, Johnson JP, Winkelstein JA, Yolken RH. Oral administration of human serum immunoglobulin in immunodeficient patients with viral gastroenteritis. A pharmacokinetic and functional analysis. J Clin Invest. 1985;76(6):2362-2367. doi: 10.1172/jci1 12248.