18. Nutritional status and related factors in patients with head and neck cancer undergoing radiotherapy at Hanoi Oncology Hospital in 2021

Nguyen Thi Loan, Nguyen Quang Dung, Bui Vinh Quang, Tran Chau Quyen, Bui Thi Kim Hue, Tran Thi Nam

Main Article Content

Abstract

This study aimed to evaluate the nutritional status and describe associated factors of patients with head and neck cancer undergoing radiotherapy. This was a cross-sectional study on 150 patients, mean age of 53.3 ± 9.15. The results showed that according to PG-SGA (Patient - Generated Subjective Global Assessment), 78.6% were malnourished or at risk of malnutrition (PG-SGA B 47.3%, PG-SGA C 31.3%). The nutritional status was worse in nasopharynx, larynx, and oral cavity (p = 0.016), advanced stages III, IV (p = 0.013), and use of concomitant chemotherapy (p < 0.01). Weight, Mid Arm Circumference, Calf Circumference, Albumin, and haemoglobin decreased gradually according to the severity of malnutrition (p < 0.05). Furthermore, the nutrition status was strongly associated with the quality of life (p < 0.05). Patients with head and neck cancers are susceptible to malnutrition during radiotherapy, so nutritional status should be screened, assessed, and intervened during the treatment process.

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References

1. Capozzi LC, McNeely ML, Lau HY, et al. Patient-reported outcomes, body composition, and nutrition status in patients with head and neck cancer: Results from an exploratory randomized controlled exercise trial. Cancer. 2016;122(8):1185-1200. doi: 10.1002/cncr.29 863.
2. Nugent B, Lewis S, O’Sullivan JM. Enteral feeding methods for nutritional management in patients with head and neck cancers being treated with radiotherapy and/or chemotherapy. Cochrane Database Syst Rev. 2013;(1):CD007904. doi: 10.1002/14651858.C D007904.pub3.
3. Langius JAE, Zandbergen MC, Eerenstein SEJ, et al. Effect of nutritional interventions on nutritional status, quality of life and mortality in patients with head and neck cancer receiving (chemo) radiotherapy: a systematic review. Clinical Nutrition. 2013;32(5):671-678. doi: 10.1016/j.clnu.2013.06.012.
4. M L, B H, I J, E A. Eating problems and weight loss for patients with head and neck cancer: a chart review from diagnosis until one year after treatment. Cancer Nurs. 2005;28(6):425-435. doi: 10.1097/00002820-2 00511000-00004.
5. Hoàng Việt Bách, Trần Thị Thủy, và cs. Tình trạng dinh dưỡng bệnh nhân ung thư khoang miệng. Bệnh viện K năm 2018. Tạp chí Nghiên cứu Y học. 2019;120(4):9-26.
6. Citak E, Tulek Z, Uzel O. Nutritional status in patients with head and neck cancer undergoing radiotherapy: a longitudinal study. Support Care Cancer. 2019;27(1):239-247. doi: 10.1007/s00520-018-4319-6.
7. Sourati A, Ameri A, Malekzadeh M. Oral Mucositis. In: Sourati A, Ameri A, Malekzadeh M, eds. Acute Side Effects of Radiation Therapy: A Guide to Management. Springer International Publishing; 2017:53-78. doi: 10.1007/978-3-31 9-55950-6_6.
8. Bauer J, Capra S, Ferguson M. Use of the scored Patient-Generated Subjective Global Assessment (PG-SGA) as a nutrition assessment tool in patients with cancer. Eur J Clin Nutr. 2002;56(8):779-785. doi: 10.1038/sj.ejcn.1601412.
9. National Health and Nutrition Examination Survey (NHANES) (2011) Anthropometry procedure manual.
10. Bjordal K, de Graeff A, Fayers PM, et al. A 12 country field study of the EORTC QLQ-C30 (version 3.0) and the head and neck cancer specific module (EORTC QLQ-H&N35) in head and neck patients. European Journal of Cancer. 2000;36(14):1796-1807. doi: 10.1016/S0959-8049(00)00186-6.
11. Bùi Thế Anh, Phạm Tuấn Cảnh. Validation of QLQ-H&N35 (Vietnamese version). Asia-Pacific Organization for Cancer Prevention Regional Conference. Đại học Y Hà Nội; 2014.
12. Lambert R, Sauvaget C, de Camargo Cancela M, Sankaranarayanan R. Epidemiology of cancer from the oral cavity and oropharynx. Eur J Gastroenterol Hepatol. 2011;23(8):633-641. doi: 10.1097/MEG.0b013e3283484795.
13. Unsal D, Mentes B, Akmansu M, Uner A, Oguz M, Pak Y. Evaluation of nutritional status in cancer patients receiving radiotherapy: A prospective study. American Journal of Clinical Oncology. 2006;29(2):183-188. doi: 10.1097/01.coc.0000198745.94757.ee.
14. Phạm Thị Tuyết Chinh, Nguyễn Thùy Linh, Tạ Thanh Nga, và cs. Tình trạng dinh dưỡng và chất lượng cuộc sống của người bệnh ung thư đường tiêu hóa sau 2 tháng điều trị hóa chất tại Bệnh viện Đại học Y Hà Nội. Tạp chí nghiên cứu Y học. 2019);120(4):1-8.
15. Phạm Thị Thanh Hoa, Lê Thị Hương. Tình trạng dinh dưỡng và chất lượng cuọc sống của bệnh nhân ung thư đường tiêu hóa có hóa trị tại Bệnh viện K năm 2018. Tạp chí nghiên cứu Y học. 2019:120(4):27-35.
16. Nourissat A, Bairati I, Fortin A, et al. Factors associated with weight loss during radiotherapy in patients with stage I or II head and neck cancer. Support Care Cancer. 2012;20(3):591-599. doi: 10.1007/s00520-011-1132-x.
17. Sousa IM, Bielemann RM, Gonzalez MC, et al. Low calf circumference is an independent predictor of mortality in cancer patients: A prospective cohort study. Nutrition. 2020;79-80:110816. doi: 10.1016/j.nut.2020.11 0816.
18. Linh Nguyen Thuy, Phuong Duong Thi, et al. Relationship between nutritional status and quality of life in gastrointestial cancer patients on chemotherapy. Asian Journal of Dietetics. 2019;(1):18-22.
19. Lis CG, Gupta D, Lammersfeld CA, Markman M, Vashi PG. Role of nutritional status in predicting quality of life outcomes in cancer-a systematic review of the epidemiological literature. Nutr J. 2012;11:27. doi: 10.1186/1475-2891-11-27.