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Published: 2022-06-01
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DOI: https://doi.org/10.52852/tcncyh.v153i5.864
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Vol. 153 No. 5 (2022)
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An, N. H. ., Lưu, V. Đăng ., Tôn, M. D. ., & Thông, P. M. . (2022). 22. Standard thrombectomy versus combined intravenous thrombolysis and thrombectomy: a systematic review and meta-analysis. Journal of Medical Research, 153(5), 180-190. https://doi.org/10.52852/tcncyh.v153i5.864

22. Standard thrombectomy versus combined intravenous thrombolysis and thrombectomy: a systematic review and meta-analysis

Nguyen Huu An, Vu Dang Luu, Mai Duy Ton, Pham Minh Thong

Main Article Content

Abstract

This is asystematic review and meta-analysis of randomized controlled trials (RCTs) conducted to elucidate if pre-treatment with intravenous thrombolysis is necessary before thrombectomy. A total of 6 RCTs conducted from January 2019 to March 2022 were selected to meta-analyze, including DIRECT-MT trial, DEVT trial, SKIP trial, MR CLEAN-NO IV trial, SWIFT-DIRECT trial, and DIRECT-SAFE trial. In terms of good outcomes (mRS 0-2 at 90 days), thrombectomy alone was non-inferior to combination therapy at the non-inferiority margin of -6%. The successful reperfusion rates were lower in thrombectomy alone, but symptomatic intracerebral hemorrhage rates were also lower in this therapy. Thrombectomy alone may be a reasonable option for patients at high risk of hemorrhagic transformation following revascularization.

Article Details

Keywords

thrombectomy alone, combined intravenous thrombolysis and thrombectomy, systematic review, meta-analysis

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