Article Sidebar

PDF (Tiếng Việt)
Published: 2022-06-15
Abstract Views: 645
Views PDF (Tiếng Việt): 495
DOI: https://doi.org/10.52852/tcncyh.v155i7.907
Issue
Vol. 155 No. 7 (2022)
Section
Các bài báo
How to Cite
Linh, V. H. ., Việt, N. H. ., Linh, N. Q. ., Thường, . . L. M. ., Khánh, T. V. ., Phương, L. T. ., Bình, N. T. ., Thạch, N. Đình ., & Đạt, T. T. . (2022). 1. Single nucleotide polymorphism rs2596542 impacts epstein-barr virus (EBV) quantification in undifferentiated nasopharyngeal carcinoma. Journal of Medical Research, 155(7), 1-7. https://doi.org/10.52852/tcncyh.v155i7.907

1. Single nucleotide polymorphism rs2596542 impacts epstein-barr virus (EBV) quantification in undifferentiated nasopharyngeal carcinoma

Vu Hai Linh, Nguyen Hoang Viet, Nguyen Quy Linh, Le Manh Thuong, Tran Van Khanh, Le Thi Phuong, Nguyen Thanh Binh, Nguyen Dinh Thach, Ta Thanh Dat

Main Article Content

Abstract

MICA (Major histocompatibility complex class I-related gene A) belongs to MHC class I, is an antigen with high expression on tumor cell’s surface or infection cells, and plays an important role in immune cell attack and killing target cells which have MICA expression on the surface. Previously, we demonstrated that T allele of rs2596542, located at 5’-UTR region in MICA gene, was predominant in nasopharyngeal carcinoma. However, Epstein-barr virus (EBV) is also known as a high risk factor for nasopharyngeal carcinoma but the association between EBV status and rs2596542 remains unclear. Therefore, we analyzed the impact of rs2596542 on EBV status on 100 undifferentiated nasopharyngeal carcinoma tissue samples by Realtime-PCR method. The results demonstrated EBV in tumor tissues was significantly expressed in TT genotyped (p = 0.001) and T allele (p = 0.005), whichmay further suggest the influence of EBV on nasopharyngeal carcinoma. Results suggested that not only rs2596542 but also EBV status will be a potential biomarker for screening and diagnosis in undifferentiated nasopharyngeal carcinoma-related virus.

Article Details

Keywords

rs2596542, Epstein-Barr virus, undifferentiated nasopharyngeal carcinoma

References

1. He M-L, Luo MX-M, Lin MC, Kung H. MicroRNAs: potential diagnostic markers and therapeutic targets for EBV-associated nasopharyngeal carcinoma. Biochim Biophys Acta. 2012;1825(1):1-10. doi: 10.1016/j.bbcan. 2011.09.001.
2. Bei J-X, Li Y, Jia W-H, et al. A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci. Nat Genet. 2010;42(7):599-603. doi: 10.1 038/ng.601.
3. Tsao SW, Tsang CM, Lo KW. Epstein-Barr virus infection and nasopharyngeal carcinoma. Philos Trans R Soc B Biol Sci. 2017;372(1732):20160270. doi: 10.1098/rstb. 2016.0270.
4. Eagle RA, Trowsdale J. Promiscuity and the single receptor: NKG2D. Nat Rev Immunol. 2007;7(9):737-744. doi: 10.1038/nri2144.
5. Diefenbach A, Raulet DH. Strategies for target cell recognition by natural killer cells. Immunol Rev. 2001;181:170-184. doi: 10.1034/j.1600-065x.2001.1810114.x.
6. Yang X, Kuang S, Wang L, Wei Y. MHC class I chain-related A: Polymorphism, regulation and therapeutic value in cancer. Biomed Pharmacother. 2018;103:111-117. doi: 10.1016/j.biopha.2018.03.177.
7. Chen D, Gyllensten U. MICA polymorphism: biology and importance in cancer. Carcinogenesis. 2014;35(12):2633-2642. doi: 10.1093/carcin/bgu215.
8. Wang YJ, Zhang NJ, Chen E, Chen CJ, Bu YH, Yu P. Allele polymorphism and haplotype diversity of MICA/B in Tujia nationality of Zhangjiajie, Hunan Province, China. Hum Immunol. 2016;77(5):411-417. doi: 10.1016/j.h umimm.2016.03.005.
9. Nguyễn PT, Vũ HL, Nguyễn VC, et al. Nghiên cứu xác định đa hình đơn Nucleotide RS2596542 của gen mica ở bệnh nhân ung thư vòm họng. 2021;05(03). doi: 10.38148/JH DS.0503SKPT21-012.
10. Luo X, Wang Y, Shen A, Deng H, Ye M. Relationship between the rs2596542 polymorphism in the MICA gene promoter and HBV/HCV infection-induced hepatocellular carcinoma: a meta-analysis. BMC Med Genet. 2019;20:142. doi: 10.1186/s12881-019-0871-2.
11. Petersson F. EBV-Associated non-keratinizing nasopharyngeal carcinoma with prominent spindled cell and whorling patterns: A previously unreported histological variant in a patient presenting with dermatomyositis. Head Neck Pathol. 2019;14(1):203-207. doi: 10.1007/s12105-019-01019-z.
12. Choy M-K, Phipps ME. MICA polymorphism: biology and importance in immunity and disease. Trends Mol Med. 2010;16(3):97-106. doi: 10.1016/j.molmed.201 0.01.002.
13. Kuang X-J, Mo D-C, Qin Y, et al. Single nucleotide polymorphism of rs2596542 and the risk of hepatocellular carcinoma development: A meta-analysis. Medicine (Baltimore). 2019;98(11):e14767. doi: 10.1097/MD.0000000000014767.
14. Jiang X, Zou Y, Huo Z, Yu P. Association of major histocompatibility complex class I chain-related gene A microsatellite polymorphism and hepatocellular carcinoma in South China Han population. Tissue Antigens. 2011;78(2):143-147. doi: 10.1111/j.1399-0039.2011.01693.x.
15. Vallian S, Rad MJ, Tavallaei M, Tavassoli M. Correlation of major histocompatibility complex class I related A (MICA) polymorphism with the risk of developing breast cancer. Med Oncol Northwood Lond Engl. 2012;29(1):5-9. doi: 10.1007/s12032-010-9776-9.
16. Lo PHY, Urabe Y, Kumar V, et al. Identification of a functional variant in the MICA promoter which regulates MICA expression and increases HCV-related hepatocellular carcinoma risk. PLOS ONE. 2013;8(4):e61279. doi: 10.1371/journal.pone.0061279.
17. Marangon CG, de Bitencorte JT, Michita RT, et al. Association between MICA rs2596542 polymorphism with the risk of hepatocellular carcinoma in chronic Hepatitis C patients. Pathol Oncol Res. 2020;26(3):1519-1525. doi: 10.1007/s12253-019-00738-6.
18. Kumar V, Kato N, Urabe Y, et al. Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma. Nat Genet. 2011;43(5):455-458. doi: 10.1038/ng.809.
19. Wang H, Cao H, Xu Z, Wang D, Zeng Y. SNP rs2596542G>A in MICA is associated with risk of hepatocellular carcinoma: a meta-analysis. Biosci Rep. 2019;39(5):BSR20181400. doi: 10.1042/BSR20181400.