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Published: 2022-06-15
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DOI: https://doi.org/10.52852/tcncyh.v155i7.907
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Vol. 155 No. 7 (2022)
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Các bài báo
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Linh, V. H. ., Việt, N. H. ., Linh, N. Q. ., Thường, . . L. M. ., Khánh, T. V. ., Phương, L. T. ., Bình, N. T. ., Thạch, N. Đình ., & Đạt, T. T. . (2022). 1. Single nucleotide polymorphism rs2596542 impacts epstein-barr virus (EBV) quantification in undifferentiated nasopharyngeal carcinoma. Journal of Medical Research, 155(7), 1-7. https://doi.org/10.52852/tcncyh.v155i7.907

1. Single nucleotide polymorphism rs2596542 impacts epstein-barr virus (EBV) quantification in undifferentiated nasopharyngeal carcinoma

Vu Hai Linh, Nguyen Hoang Viet, Nguyen Quy Linh, Le Manh Thuong, Tran Van Khanh, Le Thi Phuong, Nguyen Thanh Binh, Nguyen Dinh Thach, Ta Thanh Dat

Main Article Content

Abstract

MICA (Major histocompatibility complex class I-related gene A) belongs to MHC class I, is an antigen with high expression on tumor cell’s surface or infection cells, and plays an important role in immune cell attack and killing target cells which have MICA expression on the surface. Previously, we demonstrated that T allele of rs2596542, located at 5’-UTR region in MICA gene, was predominant in nasopharyngeal carcinoma. However, Epstein-barr virus (EBV) is also known as a high risk factor for nasopharyngeal carcinoma but the association between EBV status and rs2596542 remains unclear. Therefore, we analyzed the impact of rs2596542 on EBV status on 100 undifferentiated nasopharyngeal carcinoma tissue samples by Realtime-PCR method. The results demonstrated EBV in tumor tissues was significantly expressed in TT genotyped (p = 0.001) and T allele (p = 0.005), whichmay further suggest the influence of EBV on nasopharyngeal carcinoma. Results suggested that not only rs2596542 but also EBV status will be a potential biomarker for screening and diagnosis in undifferentiated nasopharyngeal carcinoma-related virus.

Article Details

Keywords

rs2596542, Epstein-Barr virus, undifferentiated nasopharyngeal carcinoma

References

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