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Published: 2022-10-06
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DOI: https://doi.org/10.52852/tcncyh.v157i9.933
Issue
Vol. 157 No. 9 (2022)
Section
Các bài báo
How to Cite
Họa, L. T. ., Giang, L. H. ., Cường, Đỗ D. ., & Hương, P. T. T. . (2022). 27. Case report of disseminated Histoplasma and bone marrow CMV infection in HIV-non-confirmed patients. Journal of Medical Research, 157(9), 232-238. https://doi.org/10.52852/tcncyh.v157i9.933

27. Case report of disseminated Histoplasma and bone marrow CMV infection in HIV-non-confirmed patients

Le Thi Hoa, Luong Huong Giang, Do Duy Cuong, Pham Thi Thao Huong

Main Article Content

Abstract

We report on a case of concurrent disseminated histoplasmosis and cytomegalovirus (CMV) infection of bone marrow in a non-HIV-infected patient diagnosed and treated at the National Centre of Tropical Diseases, Bach Mai Hospital. This is the first case reported in Vietnam. A 52-year-old male patient with a history of good health was in hospital because of fever lasting more than 1 month including weight loss. Myelogram and a bone marrow biopsy showed a fungal infection in the bone marrow and an owl's eye image. CMV PCR results in blood and bone marrow fluid were positive, bone marrow culture after 33 days identified Histoplasma capsulatum. The patient was successfully treated with Amtrophotret, Ganciclovir inpatient for 14 days and continued outpatient Itraconazole, valganciclovir. The occurrence of disseminated histoplasmosis in Vietnam is rare, but co-infection with CMV in healthy individuals is reported for the first time in Vietnam. Further research is needed on this particular case.

Article Details

Keywords

Histoplasma, CytomegaloVirus (CMV), HIV-non-confirmed patients

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