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Published: 2022-08-31
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DOI: https://doi.org/10.52852/tcncyh.v156i8.999
Issue
Vol. 156 No. 8 (2022)
Section
Các bài báo
How to Cite
Huy, H. Q., Khoa, P. Đăng, Hoan, P. T., & Phấn, T. Đức. (2022). 1. Mutation tp53 gene identification in different formats of skin cancer using gene sequencing. Journal of Medical Research, 156(8), 1-10. https://doi.org/10.52852/tcncyh.v156i8.999

1. Mutation tp53 gene identification in different formats of skin cancer using gene sequencing

Ho Quang Huy, Pham Dang Khoa, Phan Thi Hoan, Tran Duc Phan

Main Article Content

Abstract

Skin cancers are increasingly on the rise with a series of change agents disrupting cell division inducing unlimited proliferation and cell differentiation disorders; however, the body has mechanisms to protect against skin cancer. One of the main factors is P53 protein encoded by the TP53 gene. When this gene is mutated, there is loss of function triggering tumor cells development . Research of TP53 gene mutations in skin cancer tissue will contribute to understanding the mechanism causing cancer and support clinicians to plan for treatments especially radiotherapy. By gene sequencing of skin cancer of 63 patients initially, we identified mutation in gene TP53 in different forms ; mutation in the exons held 27%, transformation in the intron segments accounted for 95.2%. We identified 52 transformation positions in gene TP53, of which 10 mutations were found in the exons and 42 changes in the intron segments.


 

Article Details

Keywords

Skin cancer, gene mutation, sequencing, TP53

References

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