Association between serum β-CTX levels and vertebral fractures in women with primary osteoporosis
Main Article Content
Abstract
This cross-sectional study investigated the association between serum β-CTX levels and prevalent vertebral fractures in 85 women with primary osteoporosis at People’s Hospital 115 between June 2025 and January 2026. Patients were 60 years old or older. Sixteen patients (18.8%) had vertebral fractures, predominantly at L1 and T12. Univariate analysis showed that patients with vertebral fractures had significantly higher β-CTX concentrations compared with those without fractures (p < 0.05). In multivariable Firth’s logistic regression, β-CTX ≥ 316 pg/mL (OR = 4.17; 95% CI: 1.20 – 15.13; p = 0,025) and history of falls (OR = 6.42; 95% CI: 11.44 - 30.64; p = 0.015) were identified as independent associated factors for vertebral fractures. β-CTX ≥ 316 pg/mL and prior falls were strongly associated with prevalent vertebral fractures. Assessment of β-CTX in combination with bone mineral density measurement may facilitate the identification of individuals with excessive bone resorption beyond physiological levels and support risk stratification in clinical practice.
Article Details
Keywords
β-CTX, primary osteoporosis, vertebral fractures, bone mineral density
References
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