The association of phosphorylated insulin-like growth factor binding protein-1 (phIGFBP-1) and cervical parameters in the prediction of preterm delivery
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Abstract
This prospective cohort study was conducted on 150 pregnant women diagnosed with threatened preterm labor at Can Tho Obstetrics and Gynecology Hospital. Clinical findings showed a mean cervical length (CL) of 27.09 mm (with 36.67% having CL < 25 mm) and a phIGFBP-1 positivity rate of 48.7%. The preterm birth rate in the phIGFBP-1 (+) group was 54.8%, significantly higher than the negative group (24.7%) (p < 0.001), with a 3.7-fold increase in the risk of preterm birth. The combined predictive model-incorporating Uterocervical Angle (UCA), Cervical Length (CL), and phIGFBP-1-yielded an Area Under the Curve (AUC) of 0.731, compared to CL measurement alone (AUC = 0.696). This integrated model provides a risk stratification tool, enabling the identification of high-risk pregnancies for timely intervention while minimizing overtreatment and unnecessary hospital admissions for low-risk groups
Article Details
Keywords
phIGFBP-1, preterm birth
References
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