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Published: 2022-10-06
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DOI: https://doi.org/10.52852/tcncyh.v157i9.1047
Issue
Vol. 157 No. 9 (2022)
Section
Các bài báo
How to Cite
Hường, N. T. T. ., & Quảng, L. V. . (2022). 7. The prognostic role of Child-Pugh score in hepatocellular carcinoma patients treated with Sorafenib. Journal of Medical Research, 157(9), 55-62. https://doi.org/10.52852/tcncyh.v157i9.1047

7. The prognostic role of Child-Pugh score in hepatocellular carcinoma patients treated with Sorafenib

Nguyen Thi Thu Huong, Le Van Quang

Main Article Content

Abstract

Sorafenib has been approved for treatment of advanced hepatocellular carcinoma (HCC) since 2009; however, there were few studies evaluating prognostic factors in patients treated with this drug, including the severity of cirrhosis according to Child-Pugh in Vietnam. We conducted a descriptive study in 110 HCC patients treated at National Cancer Hospital and Hanoi Medical University Hospital from January 2010 to December 2018, in order to evaluate the role of Child-Pugh score to sorafenib treatment. The proportion of Child-Pugh A and B patients were 90.1% and 9.9%. The results between the two groups of CP A compared with CP B are as follows: the disease control rate was 60.6% vs 45.5% (p = 0.352), the median PFS was 4.7 months vs 2.9 months (p = 0.097); the median OS was 8.7 months vs 2.7 months (p < 0.001). The median OS of CP score was 5, 6, 7 and ≥ 8 points, and 10.6 months, 3.4 months, 5.9 months and 1.8 months (p < 0.001). Multivariate analysis showed that overall survival of CP A patients was 2.805 times longer than that of CP B patients (HR = 2.805, 95%CI: 1.250 - 6.290, p = 0.012). We concluded that Child-Pugh score was an independent predictor of the overall survival.

Article Details

Keywords

hepatocellular carcinoma, Sorafenib, Child-Pugh score

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