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Published: 2023-01-10
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DOI: https://doi.org/10.52852/tcncyh.v160i12V1.1157
Issue
Vol. 160 No. 12V1 (2022)
Section
Các bài báo
How to Cite
Nhi, T. T. D. ., & Nhung, P. H. . (2023). 4. The amikacin mic distribution of Klebsiella pneumoniae . Journal of Medical Research, 160(12V1), 26-32. https://doi.org/10.52852/tcncyh.v160i12V1.1157

4. The amikacin mic distribution of Klebsiella pneumoniae

Than Thi Dung Nhi, Pham Hong Nhung

Main Article Content

Abstract

Amikacin MIC value of 247 Klebsiella pneumoniae strains isolated from the ICU, Bach Mai Hospital in 2019 - 2021 were determinedby a broth microdilution method. The sensitivity to various antibiotics was also determined according to the amikacin MIC distribution of the bacteria. The result showed that the susceptibility rate of Klebsiella pneumoniae to amikacin was relatively high (76.9%). The distribution of bacteria according to the amikacin MIC was not uniform, in which strains with MIC from 1 - 4 µg/mL represented 55.9% and strains with MIC equal to 2 were most prevalent. Bacteria with MIC ≤ 8 µg/mL accounted for 65.6% and they were relatively sensitive to fosfomycin (80%), gentamicin (63%), and carbapenem (about 50%). Strains with amikacin MIC from 16 - 32 µg/mL (14.5%) were less susceptible to the aforementioned antibiotics by 60%, 25%, and 5.6%, respectively. With group resistant to amikacin with MIC > 32 µg/mL, the sensitivity to all tested antibiotics was less than 30%.

Article Details

Keywords

Klebsiella pneumoniae, amikacin, MIC

References

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