Tác nhân ngộ độc và các mối liên quan ở bệnh nhân ngộ độc cấp có tổn thương thận

Abstract

The study aimed to investigate the causes of poisoning and their association with clinical, subclinical and characteristics of acute kidney injury in poisoned patients with acute kidney injury. A cross-sectional, prospective study on 73 acute poisoned patients with acute kidney injury treated at the Poison Control Center, Bach Mai Hospital was conducted from July 2019 to July 2020. The study variables were collected from standardized medical records. The results showed that the most common poisoning agent was agricultural chemical pesticides (28.8%), followed by narcotics (24.7%), other prescribed pharmaceuticals (17.8%), alcohol (15.1%), other agents (13.6%). Severe symptoms most commonly encountered in narcotics poisoning were hypotension (61.1%), respiratory failure (83.3%), altered consciousnes (83.3%), multi-organ failure (88.9%), hyperkalemia (77.8%), rhabdomyolysis (66.7%), and increase in lactate (83.3%) which were higher than that of other poisoning agents. Agricultural chemical pesticides had the highest rate of increased kidney injury after hospital admission (81%). The highest mortality was due to pesticides (57.1%), alcohol (45.5%), other agents (20%), prescribed drugs (15.4%), and narcotics (5.6%). Conclusion: The results identified  common acute poisoning agents with acute kidney injury and their association with clinical, subclinical and acute kidney injury characteristics support treatment plan  and patient prognosis.