18. Acute and sub-chronic toxicity of Ich Nieu Khang tablet
Main Article Content
Abstract
This study aimed to evaluate the acute and sub-chronic toxicity of Ich Nieu Khang tablet in experimental animals. The acute toxicity was performed in Swiss mice based on the Litchfield - Wilcoxon method. The sub-chronic toxicity was evaluated in Wistar rats according to the World Health Organization's guidance. The results showed that the highest dose of Ich Nieu Khang tablet (31.5 g/kg b.w./day, equivalent to 41.66 times as high as the maximal recommended human dose) did not show acute oral toxicity in mice and the median lethal dose (LD50) was not determined. Administration of Ich Nieu Khang tablet at these doses: 0.378 g/kg b.w./day (equivalent to clinical dose) and 1.134 g/kg body weight (three times as high as the clinical dose) in 4 weeks did not produce any significant detrimental effect on the body weight, hematological and biochemical parameters, as well as the gross and microscopic images of the rats’ liver and kidney, in comparison to the control group.
Article Details
Keywords
Acute toxicity, Sub - chronic toxicity, Experimental animals, Ich Nieu Khang tablet
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