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Published: 2024-03-29
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DOI: https://doi.org/10.52852/tcncyh.v175i2.2265
Issue
Vol. 175 No. 2 (2024)
Section
Các bài báo
How to Cite
Hậu, P. V., Hưng, L. V., Lượng, V. H., Vinh, N. T. H., Hoa, P. Q., My, L. H., An, N. V., Hoàng, L. H., Việt, N. H., Vân, P. T., Hiền, T. T. T., Bình, N. T., & Hải, L. H. L. (2024). 15. Prevalence of antimicrobial resistance of common bacteria isolated from blood cultures at E Hospital in 2023. Journal of Medical Research, 175(2), 118-128. https://doi.org/10.52852/tcncyh.v175i2.2265

15. Prevalence of antimicrobial resistance of common bacteria isolated from blood cultures at E Hospital in 2023

Phan Van Hau, Le Van Hung, Vu Huy Luong, Nguyen Thi Ha Vinh, Pham Quynh Hoa, Le Huyen My, Nguyen Van An, Le Huy Hoang, Nguyen Hoang Viet, Pham Thi Van, Truong Thi Thu Hien, Nguyen Thanh Binh, Le Ha Long Hai

Main Article Content

Abstract

Bloodstream infections are severe infections that kill millions of people annually worldwide. This study aims to evaluate the prevalence and antimicrobial resistance of bacterial strains associated with bloodstream infection at E Hospital in 2023. Out of 2,094 blood culture samples, 275 bacterial strains were isolated, constituting a prevalence rate of 13.1%. The most common pathogens isolated were E. coli (29.1%), K. pneumoniae (18.5%), and S. aureus (13.5%). Notably, 58.1% of E. coli and 2.4% of K. pneumoniae were found to produce extended-spectrum beta-lactamase. Regarding antibiotic susceptibility, E. coli exhibited high sensitivity to imipenem (100%), meropenem (100%) and ertapenem (96.8%). For K. pneumoniae, the highest susceptibility was to amikacin (70.7%) and gentamicin (65.9%). For S. aureus, the highest resistance was to benzylpenicillin at 94.1%, while methicillin resistance was identified in 61.8% of cases. Importantly, no vancomycin-resistant strains were detected. The findings highlight the frequent occurrence of elevated resistance rates among E. coli, K. pneumoniae, and S. aureus to commonly prescribed antibiotics. Therefore, this study underscores the importance of rigorous infection control measures and judicious antibiotic usage to prevent the spread of antibiotic-resistant bacterial strains.

Article Details

Keywords

Bloodstream infection, septicemia, antimicrobial resistance, E Hospital

References

1. Bộ Y Tế (2015). Hướng dẫn chẩn đoán và điều trị một số bệnh truyền nhiễm, 79-85.
2. Rudd KE, Johnson SC, Agesa KM, et al. Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study. Lancet. 2020;395(10219):200-211. doi:10.1016/S0140-6736(19)32989-7
3. Van An N, Hoang LH, Le HHL, et al. Distribution and Antibiotic Resistance Characteristics of Bacteria Isolated from Blood Culture in a Teaching Hospital in Vietnam During 2014-2021. Infect Drug Resist. 2023; 16: 1677-1692. doi:10.2147/IDR.S402278.
4. Kim D, Yoon EJ, Hong JS, et al. Major Bloodstream Infection-Causing Bacterial Pathogens and Their Antimicrobial Resistance in South Korea, 2017–2019: Phase I Report From Kor-GLASS. Front Microbiol. 2022; 12: 799084. doi:10.3389/fmicb.2021.799084.
5. Diekema DJ, Hsueh PR, Mendes RE, et al. The Microbiology of Bloodstream Infection: 20-Year Trends from the SENTRY Antimicrobial Surveillance Program. Antimicrob Agents Chemother. 2019; 63(7): e00355-19. doi:10.1128/AAC.00355-19.
6. Licata F, Quirino A, Pepe D, Matera G, Bianco A. Antimicrobial Resistance in Pathogens Isolated from Blood Cultures: A Two-Year Multicenter Hospital Surveillance Study in Italy. Antibiotics (Basel). 2020; 10(1): 10. doi:10.3390/antibiotics10010010.
7. Liu VX, Fielding-Singh V, Greene JD, et al. The Timing of Early Antibiotics and Hospital Mortality in Sepsis. Am J Respir Crit Care Med. 2017; 196(7): 856-863. doi:10.1164/rccm.201609-1848OC.
8. Bộ y tế (2017). Hướng dẫn thực hành kỹ thuật xét nghiệm vi sinh lâm sàng, Nhà xuất bản y học, 93-100.
9. Lin PC, Chang CL, Chung YH, Chang CC, Chu FY. Revisiting factors associated with blood culture positivity: Critical factors after the introduction of automated continuous monitoring blood culture systems. Medicine (Baltimore). 2022; 101(30): e29693. doi:10.1097/MD.0000000000029693.
10. Li K, Li L, Wang J. Distribution and Antibiotic Resistance Analysis of Blood Culture Pathogens in a Tertiary Care Hospital in China in the Past Four Years. IDR. 2023;16:5463-5471. doi:10.2147/IDR.S423660.
11. vom Steeg LG, Klein SL. SeXX Matters in Infectious Disease Pathogenesis. PLoS Pathog. 2016; 12(2): e1005374. doi:10.1371/journal.ppat.1005374.
12. Hu F, Zhu D, Wang F, Wang M. Current Status and Trends of Antibacterial Resistance in China. Clinical Infectious Diseases. 2018; 67(suppl_2): S128-S134. doi:10.1093/cid/ciy657.
13. Quế Trâm Anh. Khảo sát sự đề kháng kháng sinh của các vi khuẩn gây nhiễm khuẩn huyết được phân lập tại trung tâm bệnh nhiệt đới, bệnh viện hữu nghị đa khoa nghệ an. Published online September 2, 2021.