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Published: 2025-09-30
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DOI: https://doi.org/10.52852/tcncyh.v194i9.3637
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Vol. 194 No. 9 (2025)
Section
Các bài báo
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Quỳnh, N. Đức, Hà, N. T. T., Cường, B. V., Thảo, P. T. N., Hải, H. B., Sơn, Đỗ N., Giang, B. T. H., & Chính, L. Q. (2025). 8. Characteristics and factors related to mortality when performing invasive mechanical ventilation for intensive care patients. Journal of Medical Research, 194(9), 65-76. https://doi.org/10.52852/tcncyh.v194i9.3637

8. Characteristics and factors related to mortality when performing invasive mechanical ventilation for intensive care patients

Nguyen Duc Quynh, Nguyen Thi Thu Ha, Bui Van Cuong, Pham Thi Ngoc Thao, Hoang Bui Hai, Do Ngoc Son, Bui Thi Huong Giang, Luong Quoc Chinh

Main Article Content

Abstract

Invasive mechanical ventilation (IMV) is a standard life-support interventionfor patients with respiratory failure; however, it is associated with complications and mortality. To identify factors related to mortality, we conducted this study to describe the characteristics of patients receiving IMV and the associated risk factors for in-hospital mortality. A prospective, multicenter, cross-sectional study was conducted from November 1to November 30, 2022. The study included 182 patients who required IMV for more than 12 hours across five intensive care units (ICUs) in five hospitals. The median age was high, with a median SAPS3 score of 55 (IQR 48 - 65) and a median SOFA score of 6 (IQR 4 - 9). The primary indication for IMV was respiratory disease (77.5%). At the time of IMV initiation, 55.6% of patients had hypoxemia. Volume-controlled invasive mechanical ventilation was the most used mode (71.4%), and 67% of patients underwent a weaning process. The overall mortality rate in the ICU was 34.1%. In the univariate analysis, factors associated with mortality included SAPS3 score (OR = 1.03; 95% CI: 1.01 - 1.06; p < 0.01), time from hospital admission to ICU admission > 24 hours (OR = 2.08; 95% CI: 1.07 - 4.03; p = 0.03), anemia (OR = 2.7; 95% CI: 1.24 - 5.86; p = 0.012), hypoxemia at the start of IMV (OR = 2.17; 95% CI: 1.14 - 4.13; p = 0.018), received continuous neuromuscular blockade (OR = 3.27; 95% CI: 1.31 - 8.16; p = 0.01), sepsis (OR = 2.66; 95% CI: 1.04 - 6.82; p = 0.042), andusage of vasopressors (OR = 3.5; 95% CI: 1.83 - 6.69; p < 0.01). In the multivariate logistic regression analysis, the independent factors associated with mortality were time from hospital admission to ICU admission > 24 hours (OR = 2.13; 95% CI: 1.01 - 4.49; p = 0.048) andusage of vasopressors (OR = 2.59; 95% CI: 1.23 - 5.49; p = 0.013). Conclusion: The majority of patients initiated on IMV presented with severe respiratory conditions and multi-organ failure. Timely transfer to the ICU and hemodynamic optimization during ventilation are critical strategies to improve outcomes in this population.

Article Details

Keywords

Mechanical ventilation, intensive care units, characteristic, mortality

References

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